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Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis : a novel glycobiomarker for non-alcoholic steatohepatitis

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Title: Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis : a novel glycobiomarker for non-alcoholic steatohepatitis
Authors: Ogawa, Koji Browse this author →KAKEN DB
Kobayashi, Takashi Browse this author
Furukawa, Jun-ichi Browse this author →KAKEN DB
Hanamatsu, Hisatoshi Browse this author →KAKEN DB
Nakamura, Akihisa Browse this author
Suzuki, Kazuharu Browse this author
Kawagishi, Naoki Browse this author →KAKEN DB
Ohara, Masatsugu Browse this author
Umemura, Machiko Browse this author
Nakai, Masato Browse this author
Sho, Takuya Browse this author
Suda, Goki Browse this author →KAKEN DB
Morikawa, Kenichi Browse this author
Baba, Masaru Browse this author
Furuya, Ken Browse this author
Terashita, Katsumi Browse this author
Kobayashi, Tomoe Browse this author
Onodera, Manabu Browse this author
Horimoto, Takahiro Browse this author
Shinada, Keisuke Browse this author
Tsunematsu, Seiji Browse this author
Tsunematsu, Izumi Browse this author
Meguro, Takashi Browse this author
Mitsuhashi, Tomoko Browse this author →KAKEN DB
Hato, Megumi Browse this author
Higashino, Kenichi Browse this author
Shinohara, Yasuro Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Issue Date: 15-Jan-2020
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 10
Issue: 1
Start Page: 321
Publisher DOI: 10.1038/s41598-019-56947-1
Abstract: Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD) that may lead to liver cirrhosis or hepatocellular carcinoma. Here, we examined the diagnostic utility of tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin (AAT-A3F), a non-invasive glycobiomarker identified in a previous study of NASH diagnosis. This study included 131 biopsy-proven Japanese patients with NAFLD. We evaluated the utility of AAT-A3F in NASH diagnosis, and conducted genetic analysis to analyse the mechanism of AAT-A3F elevation in NASH. Serum AAT-A3F concentrations were significantly higher in NASH patients than in NAFL patients, and in patients with fibrosis, lobular inflammation, and ballooning. Hepatic FUT6 gene expression was significantly higher in NASH than in NAFL. IL-6 expression levels were significantly higher in NASH than in NAFL and showed a positive correlation with FUT6 expression levels. The serum-AAT-A3F levels strongly correlated with hepatic FUT6 expression levels. AAT-A3F levels increased with fibrosis, pathological inflammation, and ballooning in patients with NAFLD and may be useful for non-invasive diagnosis of NASH from the early stages of fibrosis.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79202
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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