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The risk factors for hepatic steatosis in patients with primary aldosteronism
| Title: | The risk factors for hepatic steatosis in patients with primary aldosteronism |
| Authors: | Shibayama, Yui Browse this author | | Wada, Norio Browse this author | | Baba, Shuhei Browse this author | | Obara, Shinji Browse this author | | Sakai, Hidetsugu Browse this author | | Usubuchi, Hiroaki Browse this author | | Terae, Satoshi Browse this author →KAKEN DB | | Nakamura, Akinobu Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Non-alcoholic fatty liver disease | | Primary aldosteronism | | Intra-abdominal fat | | Obesity | | Computed tomography |
| Issue Date: | 2020 |
| Publisher: | 社団法人 日本内分泌学会 The Japan Endocrine Society |
| Journal Title: | Endocrine journal |
| Volume: | 67 |
| Issue: | 6 |
| Start Page: | 623 |
| End Page: | 629 |
| Publisher DOI: | 10.1507/endocrj.EJ19-0600 |
| Abstract: | Patients with primary aldosteronism (PA) are complicated by metabolic syndrome more frequently than those without PA. Hyperaldosteronism has been reported to be associated with a higher prevalence of non-alcoholic fatty liver disease (NAFLD). We aimed to clarify the risk factors for hepatic steatosis in the two subtypes of PA, comparing the status of hepatic steatosis in each of these subtypes. This was a retrospective observational study. We enrolled patients with an aldosterone producing adenoma (APA) (n = 33) or idiopathic hyperaldosteronism (IHA) (n = 56). Hepatic fat content was evaluated using the ratio of liver to spleen (L/S) X-ray attenuation on unenhanced computed tomography. L/S ratio <1.0 was utilized for assessing as hepatic steatosis. Age, sex distribution, visceral fat percentage (VF%), and visceral fat area (VFA) did not differ between patients with the two PA subtypes. The percentages of patients with L/S ratio <1.0 was not different between the two subtypes (APA: 21.2 % (7/33) vs. IHA: 19.6 % (11/56), p = 1.00). In both subtypes, the L/S ratio negatively correlated with VF% (APA: r = -0.66, p < 0.001; IHA: r = -0.66, p < 0.001) and with VFA (APA: r = -0.44, p < 0.01; IHA: r = -0.37, p < 0.01). The status of hepatic steatosis, evaluated using L/S ratio, did not differ between patients with APA or IHA. Hepatic steatosis was affected by the amount of visceral fat. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79203 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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