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The risk factors for hepatic steatosis in patients with primary aldosteronism

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Title: The risk factors for hepatic steatosis in patients with primary aldosteronism
Authors: Shibayama, Yui Browse this author
Wada, Norio Browse this author
Baba, Shuhei Browse this author
Obara, Shinji Browse this author
Sakai, Hidetsugu Browse this author
Usubuchi, Hiroaki Browse this author
Terae, Satoshi Browse this author →KAKEN DB
Nakamura, Akinobu Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Non-alcoholic fatty liver disease
Primary aldosteronism
Intra-abdominal fat
Computed tomography
Issue Date: 2020
Publisher: 社団法人 日本内分泌学会 The Japan Endocrine Society
Journal Title: Endocrine journal
Volume: 67
Issue: 6
Start Page: 623
End Page: 629
Publisher DOI: 10.1507/endocrj.EJ19-0600
Abstract: Patients with primary aldosteronism (PA) are complicated by metabolic syndrome more frequently than those without PA. Hyperaldosteronism has been reported to be associated with a higher prevalence of non-alcoholic fatty liver disease (NAFLD). We aimed to clarify the risk factors for hepatic steatosis in the two subtypes of PA, comparing the status of hepatic steatosis in each of these subtypes. This was a retrospective observational study. We enrolled patients with an aldosterone producing adenoma (APA) (n = 33) or idiopathic hyperaldosteronism (IHA) (n = 56). Hepatic fat content was evaluated using the ratio of liver to spleen (L/S) X-ray attenuation on unenhanced computed tomography. L/S ratio <1.0 was utilized for assessing as hepatic steatosis. Age, sex distribution, visceral fat percentage (VF%), and visceral fat area (VFA) did not differ between patients with the two PA subtypes. The percentages of patients with L/S ratio <1.0 was not different between the two subtypes (APA: 21.2 % (7/33) vs. IHA: 19.6 % (11/56), p = 1.00). In both subtypes, the L/S ratio negatively correlated with VF% (APA: r = -0.66, p < 0.001; IHA: r = -0.66, p < 0.001) and with VFA (APA: r = -0.44, p < 0.01; IHA: r = -0.37, p < 0.01). The status of hepatic steatosis, evaluated using L/S ratio, did not differ between patients with APA or IHA. Hepatic steatosis was affected by the amount of visceral fat.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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