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Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes |
| Authors: | Lahrita, Lucy Browse this author | | Moriai, Kenta Browse this author | | Iwata, Ryohei Browse this author | | Itoh, Kazuki Browse this author | | Kato, Eisuke Browse this author →KAKEN DB |
| Keywords: | Lipolysis Obesity | | Adipocyte | | Quassinoid | | Medicinal plant | | Brucea javanica |
| Issue Date: | Sep-2019 |
| Publisher: | Elsevier |
| Journal Title: | Fitoterapia |
| Volume: | 137 |
| Start Page: | 104250 |
| Publisher DOI: | 10.1016/j.fitote.2019.104250 |
| PMID: | 31271784 |
| Abstract: | Obesity is associated with a number of metabolic disorders. Lipolysis is the initial step in the metabolism of lipids stored in adipocytes and is therefore considered a therapeutic target for obesity. Quassinoids are unique terpenes found in plants of the Simaroubaceae family, which were recently reported to have lipolytic activity and to suppress weight gain. Brucea javanica is a plant employed in traditional medicines in Asia, which is known to contain various quassinoids. Here, we investigated the lipolytic activity of B. javanica extracts, and identified six quassinoids: brucein A, brucein B, brucein C, 3′-hydroxybrucein A, brusatol, and bruceantinol, which represent the bioactive principals. The quassinoids contained in B. javanica demonstrated lipolytic activity at nanomolar concentrations, which were an order of magnitude lower than those of the previously reported quassinoids, suggesting that they may be useful for the treatment of obesity. |
| Rights: | © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79214 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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