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Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes

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Title: Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytes
Authors: Lahrita, Lucy Browse this author
Moriai, Kenta Browse this author
Iwata, Ryohei Browse this author
Itoh, Kazuki Browse this author
Kato, Eisuke Browse this author →KAKEN DB
Keywords: Lipolysis Obesity
Medicinal plant
Brucea javanica
Issue Date: Sep-2019
Publisher: Elsevier
Journal Title: Fitoterapia
Volume: 137
Start Page: 104250
Publisher DOI: 10.1016/j.fitote.2019.104250
PMID: 31271784
Abstract: Obesity is associated with a number of metabolic disorders. Lipolysis is the initial step in the metabolism of lipids stored in adipocytes and is therefore considered a therapeutic target for obesity. Quassinoids are unique terpenes found in plants of the Simaroubaceae family, which were recently reported to have lipolytic activity and to suppress weight gain. Brucea javanica is a plant employed in traditional medicines in Asia, which is known to contain various quassinoids. Here, we investigated the lipolytic activity of B. javanica extracts, and identified six quassinoids: brucein A, brucein B, brucein C, 3′-hydroxybrucein A, brusatol, and bruceantinol, which represent the bioactive principals. The quassinoids contained in B. javanica demonstrated lipolytic activity at nanomolar concentrations, which were an order of magnitude lower than those of the previously reported quassinoids, suggesting that they may be useful for the treatment of obesity.
Rights: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 英介

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