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Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats
| Title: | Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats |
| Authors: | Pinyo, Jukkrapong Browse this author | | Hira, Tohru Browse this author →KAKEN DB | | Hara, Hiroshi Browse this author →KAKEN DB |
| Keywords: | GLP-1 receptor antagonist | | Glucagon-like peptide-1 | | Glucose intolerance | | Meal tolerance test | | Obesity | | diet-induced obesity | | dipeptidyl peptidase-IV | | glucagon-like peptide-1 | | high-fat/high-sucrose | | meal tolerance test | | oral glucose tolerance test |
| Issue Date: | 28-Aug-2019 |
| Publisher: | Cambridge University Press |
| Journal Title: | British journal of nutrition |
| Volume: | 122 |
| Issue: | 4 |
| Start Page: | 411 |
| End Page: | 422 |
| Publisher DOI: | 10.1017/S0007114519001223 |
| PMID: | 31352909 |
| Abstract: | Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates postprandial glycaemic response by enhancing insulin secretion. We previously demonstrated that the postprandial GLP-1 response was enhanced during the development of diet-induced obesity in rats. However, the physiological relevance of the enhanced GLP-1 response remained unclear. We aimed to determine the role of endogenous GLP-1 during obesity development. Male Sprague-Dawley rats were given either a control diet or a high-fat/high-sucrose (HFS, 30 % fat and 40 % sucrose, weight basis) diet with or without continuous administration of the GLP-1 receptor antagonist, exendin (9-39) (Ex9, 100 mu g/d), for 5 weeks. Meal tolerance tests (MTT) were performed to assess postprandial glucose, insulin and GLP-1 responses to a liquid diet administration (15 kcal (63 kJ)/10 ml per kg body weight) every 2 weeks. The AUC of postprandial glucose in the HFS group was similar to the control group in both MTT (P = 0 center dot 9665 and P = 0 center dot 3475, respectively), whereas AUC of postprandial GLP-1 (after 4 weeks,P = 0 center dot 0457) and of insulin (after 2 and 4 weeks, P = 0 center dot 0486 and P = 0 center dot 0110) was higher in the HFS group compared with the control group. In the Ex9 group, AUC of postprandial glucose (P = 0 center dot 0297 and P = 0 center dot 0486) was higher along with a lower insulin response compared with the HFS group (P = 0 center dot 0564 and P = 0 center dot 0281). These results suggest that enhancement of the postprandial GLP-1 response during obesity development has a role in maintaining a normal postprandial glycaemic response. Hence, enhancing endogenous GLP-1 secretion by certain materials could be a potential target for prevention of glucose intolerance. |
| Rights: | © The Authors 2019 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79215 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 比良 徹
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