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Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction
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| Title: | Large osteochondral defect in the lateral femoral condyle reconstructed by Atelocollagen-associated autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction |
| Authors: | Kaibara, Takuma Browse this author | | Kondo, Eiji Browse this author →KAKEN DB | | Matsuoka, Masatake Browse this author →KAKEN DB | | Iwasaki, Koji Browse this author →KAKEN DB | | Onodera, Tomohiro Browse this author →KAKEN DB | | Momma, Daisuke Browse this author →KAKEN DB | | Seito, Naoki Browse this author | | Mikami, Susumu Browse this author | | Iwasaki, Norimasa Browse this author →KAKEN DB |
| Keywords: | Osteochondral defect | | Autologous chondrocyte implantation | | Atelocollagen | | Anterior cruciate ligament reconstruction | | Orthopedics | | Knee |
| Issue Date: | 27-Jul-2020 |
| Publisher: | BioMed Central |
| Journal Title: | BMC musculoskeletal disorders |
| Volume: | 21 |
| Issue: | 1 |
| Start Page: | 494 |
| Publisher DOI: | 10.1186/s12891-020-03531-8 |
| Abstract: | Background Articular surface damage commonly associated with rupture of the anterior cruciate ligament (ACL). Large osteochondral defect, which consists of a severe depression fracture and a large cartilage defect, need to be treated due to deformation of the articular surface as it can impact the clinical outcome of ACL reconstruction. Although autologous chondrocyte implantation is one of the useful options in such cases, it can be questioned whether the reconstruction of the ACL and osteochondral defect should be performed in one procedure alone. Case presentation We report a case of a 38-year-old male with a deep depression fracture extending to the edge of the lateral femoral condyle associated with ACL injury after twisting his right knee while skiing. The patient was successfully treated with tissue-engineered cartilage transplantation covered by the periosteum with an iliac bone graft combined with anatomic double-bundle ACL reconstruction. Histopathological examination of the transplanted cartilage taken at second-look arthroscopy showed a cartilage-like tissue in the middle to deep zone in which the extracellular matrix was largely stained with Safranin O. The patient was able to return to his previous level of skiing activity without any experience of knee pain. Magnetic resonance imaging at 4 years after surgery showed that the graft integrated to the border zone and subchondral bone. The operated knee showed negative Lachman test and had a full range of motion. Conclusions To our knowledge, this is the first report of anatomic double-bundle ACL reconstruction with tissue-engineered cartilage transplantation and an iliac bone graft to restore the lateral edge of the femoral condyle. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79264 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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