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Volume 68 Number 3 >

Cold Exposure Increases Circulating miR-122 Levels via UCP1-Dependent Mechanism in Mice

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Title: Cold Exposure Increases Circulating miR-122 Levels via UCP1-Dependent Mechanism in Mice
Authors: Bariuan, Jussiaea Valente Browse this author
Okamatsu-Ogura, Yuko Browse this author →KAKEN DB
Tsubota, Ayumi Browse this author
Matsuoka, Shinya Browse this author
Saito, Masayuki Browse this author →KAKEN DB
Kimura, Kazuhiro Browse this author →KAKEN DB
Keywords: brown adipose tissue
cold exposure
skeletal muscle
uncoupling protein 1
Issue Date: Aug-2020
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 68
Issue: 3
Start Page: 187
End Page: 195
Abstract: MicroRNA(miR)-122 is highly expressed in liver and secreted into blood, which is reported to enter other tissues to modulate lipid metabolism. Brown adipose tissue (BAT) is responsible for nonshivering thermogenesis required for body temperature maintenance in cold environments. Since BAT activity is deeply related to lipid metabolism, there may be metabolic crosstalk between the liver and BAT through miR-122. In this study, we examined the effect of cold exposure on circulating miR-122 (cir-miR-122) levels in mice. Cold exposure significantly increased the expressions of Uncoupling protein 1 (Ucp1), a key molecule for thermogenesis, indicating the activation of BAT. Cold exposure significantly increased cir-miR-122 level but caused no change in miR-122 and its precursor levels in the liver. In contrast, cold exposure significantly decreased miR-122 level in the muscle, but not in BAT, suggesting that increased cir-miR-122 was due to the enhancement of its secretion from the muscle. To examine whether BAT thermogenesis was a prerequisite for increased cir-miR-122 and decreased miR-122 level in the muscle, effect of cold exposure was examined in UCP1-KO mice. While the expressions of thermogenesis-related genes in BAT, except for that of Ucp1, was increased after cold exposure, no significant changes were observed in cir-miR-122 and muscle miR-122 level in UCP1-KO mice. These results suggest that coldinduced activation of BAT thermogenesis increased cir-miR-122 through the secretion from muscle, although further study is required to find the missing link between BAT thermogenesis and miRNA secretion from the muscle.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 68 Number 3

Submitter: 獣医学部図書室

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