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Volume 68 Number 3 >

Clinical evaluation of pentosan polysulfate as a chondroprotective substance in native Mongolian horses

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Title: Clinical evaluation of pentosan polysulfate as a chondroprotective substance in native Mongolian horses
Authors: Tsogbadrakh, Mijiddorj Browse this author
Sunaga, Takafumi Browse this author →KAKEN DB
Bwalya, Eugene Browse this author
Wijekoon, Suranji Browse this author
Akaraphutiporn, Ekkapol Browse this author
Wang, Yanlin Browse this author
Mwale, Carol Browse this author
Naranbaatar, Adiya Browse this author
Kim, Sangho Browse this author
Hosoya, Kenji Browse this author →KAKEN DB
Alimaa, Damdinsuren Browse this author
Okumura, Masahiro Browse this author →KAKEN DB
Keywords: pentosan polysulfate
Issue Date: Aug-2020
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 68
Issue: 3
Start Page: 203
End Page: 208
Abstract: Pentosan polysulfate (PPS) is widely used as therapeutic intervention for joint diseases in humans and animals, while objective confirmation has not been established yet. The purpose of this study was to provide the objective measure of the efficacy of PPS. Twenty-five healthy Mongolian horses were randomly assigned in three groups. Three different doses of PPS, 0/1.2/3.0 mg/kg, were injected intramuscularly one a week for consecutive 4 weeks. On 14 and 28 days after the initial administration, relative ratios of serum COMP/CPII were 97.9/87.6/61.8 and 94.2/104.3/88.1 in 0/1.2/3.0 mg/kg PPS, respectively. The results revealed that balance of cartilage metabolism could be significantly brought to an anabolism dominant state by PPS injections in dose dependent manor in field fed horses in Mongolia.
Type: bulletin (article)
Appears in Collections:Japanese Journal of Veterinary Research > Volume 68 Number 3

Submitter: 獣医学部図書室

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