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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Preoperative chemotherapy in colorectal cancer patients with synchronous liver metastasis
| Title: | Preoperative chemotherapy in colorectal cancer patients with synchronous liver metastasis |
| Authors: | Ichikawa, Nobuki Browse this author →KAKEN DB | | Kamiyama, Toshiya Browse this author →KAKEN DB | | Yokoo, Hideki Browse this author →KAKEN DB | | Homma, Shigenori Browse this author →KAKEN DB | | Maeda, Yoshiaki Browse this author | | Shinohara, Toshiki Browse this author | | Tsuruga, Yosuke Browse this author | | Kazui, Keizo Browse this author | | Iijima, Hiroaki Browse this author | | Yoshida, Tadashi Browse this author →KAKEN DB | | Taketomi, Akinobu Browse this author →KAKEN DB |
| Keywords: | colorectal carcinoma | | liver metastasis | | oncology | | chemotherapy | | survival | | hepatectomy |
| Issue Date: | Apr-2020 |
| Publisher: | Spandidos Publications |
| Journal Title: | Molecular and clinical oncology |
| Volume: | 12 |
| Issue: | 4 |
| Start Page: | 374 |
| End Page: | 383 |
| Publisher DOI: | 10.3892/mco.2020.1992 |
| Abstract: | The response to preoperative chemotherapy is useful for predicting prognosis in unresectable and resectable disease. However, the prognostic benefit of chemotherapy prior to hepatectomy in patients with colorectal carcinoma and resectable or marginally resectable liver metastases remains unclear. The present study investigated the effect of preoperative chemotherapy on the prognosis of patients with colorectal cancer and resectable or marginally resectable synchronous liver metastasis. A total of 106 patients were retrospectively reviewed, who underwent hepatectomy for colorectal metastasis. The prognosis of 64 patients who received neoadjuvant chemotherapy (NAC) were compared with the 42 patients who did not (non-NAC). Furthermore, a total of 43 patients who responded to chemotherapy were compared with the 21 who did not. Preoperative chemotherapy was administered for 5.7 months, wherein 50 patients (78%) received a single regimen, and 54 (84%) received oxaliplatin. There were more patients with <3 metastases and maximum diameters <5 cm in the non-NAC group. The median survival time was 86.0 and 71.6 months in the NAC and non-NAC groups, respectively (P=0.33). Subgroup analysis on the basis of tumor size and number showed no prognostic differences between the two groups. The median survival time was longer in responders than in non-responders (85 vs. 56 months; P=0.01). However, the median relapse-free survival was equivalent in both groups (16.4 and 10.7 months). Preoperative chemotherapy did not prolong survival. Furthermore, it did not prevent recurrence, even in clinical responders. Therefore, it should not be routinely offered to patients with resectable liver metastasis before their hepatectomy. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79361 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 神山 俊哉
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