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Associations between allergic symptoms and phosphate flame retardants in dust and their urinary metabolites among school children

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Title: Associations between allergic symptoms and phosphate flame retardants in dust and their urinary metabolites among school children
Other Titles: Phosphate flame retardants and child allergic symptoms
Authors: Araki, Atsuko Browse this author →KAKEN DB
Bastiaensen, Michiel Browse this author
Ait Bamai, Yu Browse this author
Van den Eede, Nele Browse this author
Kawai, Toshio Browse this author
Tsuboi, Tazuru Browse this author
Ketema, Rahel Mesfin Browse this author
Covaci, Adrian Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Phosphate flame retardants
House dust
Issue Date: Oct-2018
Publisher: Elsevier
Journal Title: Environment international
Volume: 119
Start Page: 438
End Page: 446
Publisher DOI: 10.1016/j.envint.2018.07.018
Abstract: Background: Phosphate flame retardants (PFRs) are ubiquitously detected in indoor environments. Despite increasing health concerns pertaining to PFR exposure, few epidemiological studies have examined PFR exposure and its effect on children's allergies. Objectives: To investigate the association between PFRs in house dust, their metabolites in urine, and symptoms of wheeze and allergies among school-aged children. Methods: A total of 128 elementary school-aged children were enrolled. House dust samples were collected from upper-surface objects. Urine samples were collected from the first morning void. Levels of 11 PFRs in dust and 14 PFR metabolites in urine were measured. Parent-reported symptoms of wheeze, rhinoconjunctivitis, and eczema were evaluated using the International Study of Asthma and Allergies in Childhood questionnaire. The odds ratios (ORs) of the Ln transformed PFR concentrations and categorical values were calculated using a logistic regression model adjusted for sex, grade, dampness index, annual house income, and creatinine level (for PFR metabolites only). Results: The prevalence rates of wheeze, rhinoconjunctivitis, and eczema were 22.7%, 36.7%, and 28.1%, respectively. A significant association between tris(1,3-dichloroisopropyl) phosphate (TDCIPP) in dust and eczema was observed: OR (95% confidence interval), 1.44 (1.13-1.82) (>limit of detection (LOD) vs <LOD). The ORs for rhinoconjunctivitis (OR = 5.01 [1.53-16.5]) and for at least one symptom of allergy (OR = 3.87 [1.22-12.3]) in the 4th quartile of Σtris(2-chloro-isopropyl) phosphate (TCIPP) metabolites was significantly higher than those in the 1st quartile, with significant p-values for trend (Ptrend) (0.013 and 0.024, respectively). A high OR of 2.86 (1.04-7.85) (>LOD vs <LOD) was found for hydroxy tris(2-butoxyethyl) phosphate (TBOEP)-OH and eczema. OR of the 3rd tertile of bis (1,3-dichloro-2-propyl) phosphate (BDCIPP) was higher than the 1st tertile as a reference for at least one symptom (OR = 3.91 [1.25-12.3]), with a significant Ptrend = 0.020. Conclusions: We found that TDCIPP in house dust, and metabolites of TDCIPP, TBOEP and TCIPP were associated with children's allergic symptoms. Despite some limitations of this study, these results indicate that children's exposure to PFR may impact their allergic symptoms.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 荒木(池田) 敦子

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