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Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

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Title: Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma
Authors: Hayakwa, Mineji Browse this author →KAKEN DB
Ooyasu, Takayoshi Browse this author
Sadamoto, Yoshihiro Browse this author
Saito, Tomoyo Browse this author
Yoshida, Tomonao Browse this author →KAKEN DB
Katabami, Kenichi Browse this author
Wada, Takeshi Browse this author →KAKEN DB
Maekawa, Kunihiko Browse this author
Ieko, Masahiro Browse this author →KAKEN DB
Keywords: blunt trauma
Issue Date: 20-Aug-2020
Publisher: SAGE Publications
Journal Title: Clinical and applied thrombosis/hemostasis
Volume: 26
Start Page: 1076029620950825
Publisher DOI: 10.1177/1076029620950825
Abstract: We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma, where they were tumbled for 0, 250, 500, or 1000 revolutions. Creatine kinase, nucleosome, and microparticle plasma levels increased gradually with trauma severity. Strong interrelationships were observed among creatine kinase, nucleosome, and microparticle levels. Time to initiation of thrombin generation shortened with increasing trauma severity. In accordance with trauma severity, prothrombin activity decreased, but the thrombin generation ratio increased. Time to initiation of thrombin generation and the thrombin generation ratio correlated with creatine kinase levels. In anin vitrostudy, a homogenized muscle solution, which included massive nucleosomes and microparticles, showed accelerated thrombin generation of plasma from healthy subjects. Procoagulants, such as microparticles and nucleosomes, are released from destroyed parenchymal cells immediately after external traumatic force, activating the coagulation cascade. The procoagulants shorten the time to initiation of thrombin generation. Furthermore, although coagulation factors are consumed, the thrombin generation ratio increases.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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