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Establishment of an experimental model for MHC homo-to-hetero transplantation

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Title: Establishment of an experimental model for MHC homo-to-hetero transplantation
Authors: Murata, Tomoki Browse this author
Wada, Haruka Browse this author →KAKEN DB
Otsuka, Ryo Browse this author
Sasaki, Airi Browse this author
Tsuji, Hyuma Browse this author
Itoh, Mizuho Browse this author
Eguchi, Nanami Browse this author
Kawai, Tatsuo Browse this author
Seino, Ken-ichiro Browse this author →KAKEN DB
Issue Date: 11-Aug-2020
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 10
Issue: 1
Start Page: 13560
Publisher DOI: 10.1038/s41598-020-69784-4
Abstract: Preventing rejection is a major challenge in transplantation medicine, even when using pluripotent stem cell-derived grafts. In iPS cell (iPSC)-based transplantation, to reduce the risk of rejection, it is thought to be optimal that preparing the cells from donors whose human leukocyte antigen-haplotype are homozygous. Generally, this approach is referred to as major histocompatibility complex (MHC) homo-to-hetero transplantation, which is MHC-matched but minor antigen-mismatched. To investigate the immune response in the MHC homo-to-hetero transplantation, we established a murine experimental system in which MHC-matched but minor antigen-mismatched tissue (skin) grafts were transplanted into MHC-heterozygous recipients. Unexpectedly, only minor antigen-mismatched grafts were rejected at the same time points as rejection of fully allogeneic grafts. A vigorous anti-donor type T cell response was detected in vitro and conventional immunosuppressants targeting T cell activation had limited effects on controlling rejection. However, anti-donor antibodies were not detected only in the minor antigen-mismatched transplantation. This murine transplantation model can be used to further analyze immunological subjects for MHC homo-to-hetero iPSC-based transplantation.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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