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Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats

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Title: Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats
Authors: Kikuchi, Kasumi Browse this author
Murata, Miyuki Browse this author →KAKEN DB
Noda, Kousuke Browse this author →KAKEN DB
Kase, Satoru Browse this author →KAKEN DB
Tagawa, Yoshiaki Browse this author →KAKEN DB
Kageyama, Yasushi Browse this author
Shinohara, Masami Browse this author
Sasase, Tomohiko Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Issue Date: 3-Aug-2020
Publisher: Hindawi Publishing Corporation
Journal Title: Journal of Diabetes Research
Volume: 2020
Start Page: 3058547
Publisher DOI: 10.1155/2020/3058547
Abstract: Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity. SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated. The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats. The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age. Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period. Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes. The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats. Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats. By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats. The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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