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The role of Mediator and Little Elongation Complex in transcription termination

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Title: The role of Mediator and Little Elongation Complex in transcription termination
Authors: Takahashi, Hidehisa Browse this author →KAKEN DB
Ranjan, Amol Browse this author
Chen, Shiyuan Browse this author
Suzuki, Hidefumi Browse this author →KAKEN DB
Shibata, Mio Browse this author
Hirose, Tomonori Browse this author
Hirose, Hiroko Browse this author
Sasaki, Kazunori Browse this author
Abe, Ryota Browse this author
Chen, Kai Browse this author
He, Yanfeng Browse this author
Zhang, Ying Browse this author
Takigawa, Ichigaku Browse this author →KAKEN DB
Tsukiyama, Tadasuke Browse this author →KAKEN DB
Watanabe, Masashi Browse this author →KAKEN DB
Fujii, Satoshi Browse this author
Iida, Midori Browse this author
Yamamoto, Junichi Browse this author →KAKEN DB
Yamaguchi, Yuki Browse this author
Suzuki, Yutaka Browse this author →KAKEN DB
Matsumoto, Masaki Browse this author →KAKEN DB
Nakayama, Keiichi I. Browse this author
Washburn, Michael P. Browse this author
Saraf, Anita Browse this author
Florens, Laurence Browse this author
Sato, Shigeo Browse this author
Tomomori-Sato, Chieri Browse this author
Conaway, Ronald C. Browse this author
Conaway, Joan W. Browse this author
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Issue Date: 26-Feb-2020
Publisher: Nature Publishing Group
Journal Title: Nature communications
Volume: 11
Issue: 1
Start Page: 1063
Publisher DOI: 10.1038/s41467-020-14849-1
Abstract: Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we provide evidence that MED26 recruits LEC to modulate transcription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replication-dependent histone (RDH) at Cajal bodies. Our findings indicate that LEC recruited by MED26 promotes efficient transcription termination by Pol II through interaction with CBC-ARS2 and NELF/DSIF, and promotes 3' end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79483
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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