| Title: | The role of Mediator and Little Elongation Complex in transcription termination |
| Authors: | Takahashi, Hidehisa Browse this author →KAKEN DB |
| Ranjan, Amol Browse this author |
| Chen, Shiyuan Browse this author |
| Suzuki, Hidefumi Browse this author →KAKEN DB |
| Shibata, Mio Browse this author |
| Hirose, Tomonori Browse this author |
| Hirose, Hiroko Browse this author |
| Sasaki, Kazunori Browse this author |
| Abe, Ryota Browse this author |
| Chen, Kai Browse this author |
| He, Yanfeng Browse this author |
| Zhang, Ying Browse this author |
| Takigawa, Ichigaku Browse this author →KAKEN DB |
| Tsukiyama, Tadasuke Browse this author →KAKEN DB |
| Watanabe, Masashi Browse this author →KAKEN DB |
| Fujii, Satoshi Browse this author |
| Iida, Midori Browse this author |
| Yamamoto, Junichi Browse this author →KAKEN DB |
| Yamaguchi, Yuki Browse this author |
| Suzuki, Yutaka Browse this author →KAKEN DB |
| Matsumoto, Masaki Browse this author →KAKEN DB |
| Nakayama, Keiichi I. Browse this author |
| Washburn, Michael P. Browse this author |
| Saraf, Anita Browse this author |
| Florens, Laurence Browse this author |
| Sato, Shigeo Browse this author |
| Tomomori-Sato, Chieri Browse this author |
| Conaway, Ronald C. Browse this author |
| Conaway, Joan W. Browse this author |
| Hatakeyama, Shigetsugu Browse this author →KAKEN DB |
| Issue Date: | 26-Feb-2020 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Nature communications |
| Volume: | 11 |
| Issue: | 1 |
| Start Page: | 1063 |
| Publisher DOI: | 10.1038/s41467-020-14849-1 |
| Abstract: | Mediator is a coregulatory complex that regulates transcription of Pol II-dependent genes. Previously, we showed that human Mediator subunit MED26 plays a role in the recruitment of Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to regulate the expression of certain genes. MED26 plays a role in recruiting SEC to protein-coding genes including c-myc and LEC to small nuclear RNA (snRNA) genes. However, how MED26 engages SEC or LEC to regulate distinct genes is unclear. Here, we provide evidence that MED26 recruits LEC to modulate transcription termination of non-polyadenylated transcripts including snRNAs and mRNAs encoding replication-dependent histone (RDH) at Cajal bodies. Our findings indicate that LEC recruited by MED26 promotes efficient transcription termination by Pol II through interaction with CBC-ARS2 and NELF/DSIF, and promotes 3' end processing by enhancing recruitment of Integrator or Heat Labile Factor to snRNA or RDH genes, respectively. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79483 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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