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Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

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Title: Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis
Authors: Komori, Akira Browse this author
Abe, Toshikazu Browse this author →KAKEN DB
Kushimoto, Shigeki Browse this author →KAKEN DB
Ogura, Hiroshi Browse this author →KAKEN DB
Shiraishi, Atsushi Browse this author →KAKEN DB
Saitoh, Daizoh Browse this author →KAKEN DB
Fujishima, Seitaro Browse this author →KAKEN DB
Mayumi, Toshihiko Browse this author →KAKEN DB
Naito, Toshio Browse this author
Hifumi, Toru Browse this author
Shiino, Yasukazu Browse this author
Nakada, Taka-aki Browse this author →KAKEN DB
Tarui, Takehiko Browse this author
Otomo, Yasuhiro Browse this author →KAKEN DB
Okamoto, Kohji Browse this author
Umemura, Yutaka Browse this author →KAKEN DB
Kotani, Joji Browse this author →KAKEN DB
Sakamoto, Yuichiro Browse this author →KAKEN DB
Sasaki, Junichi Browse this author →KAKEN DB
Shiraishi, Shin-ichiro Browse this author →KAKEN DB
Takuma, Kiyotsugu Browse this author →KAKEN DB
Tsuruta, Ryosuke Browse this author →KAKEN DB
Hagiwara, Akiyoshi Browse this author
Yamakawa, Kazuma Browse this author →KAKEN DB
Masuno, Tomohiko Browse this author →KAKEN DB
Takeyama, Naoshi Browse this author →KAKEN DB
Yamashita, Norio Browse this author
Ikeda, Hiroto Browse this author
Ueyama, Masashi Browse this author
Fujimi, Satoshi Browse this author
Gando, Satoshi Browse this author →KAKEN DB
Issue Date: 19-Feb-2020
Publisher: Nature Publishing Group
Journal Title: Scientific reports
Volume: 10
Issue: 1
Start Page: 2983
Publisher DOI: 10.1038/s41598-020-59830-6
Abstract: The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged >= 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p=0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p=0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79484
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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