Title: | Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis |
Authors: | Komori, Akira Browse this author |
Abe, Toshikazu Browse this author →KAKEN DB |
Kushimoto, Shigeki Browse this author →KAKEN DB |
Ogura, Hiroshi Browse this author →KAKEN DB |
Shiraishi, Atsushi Browse this author →KAKEN DB |
Saitoh, Daizoh Browse this author →KAKEN DB |
Fujishima, Seitaro Browse this author →KAKEN DB |
Mayumi, Toshihiko Browse this author →KAKEN DB |
Naito, Toshio Browse this author |
Hifumi, Toru Browse this author |
Shiino, Yasukazu Browse this author |
Nakada, Taka-aki Browse this author →KAKEN DB |
Tarui, Takehiko Browse this author |
Otomo, Yasuhiro Browse this author →KAKEN DB |
Okamoto, Kohji Browse this author |
Umemura, Yutaka Browse this author →KAKEN DB |
Kotani, Joji Browse this author →KAKEN DB |
Sakamoto, Yuichiro Browse this author →KAKEN DB |
Sasaki, Junichi Browse this author →KAKEN DB |
Shiraishi, Shin-ichiro Browse this author →KAKEN DB |
Takuma, Kiyotsugu Browse this author →KAKEN DB |
Tsuruta, Ryosuke Browse this author →KAKEN DB |
Hagiwara, Akiyoshi Browse this author |
Yamakawa, Kazuma Browse this author →KAKEN DB |
Masuno, Tomohiko Browse this author →KAKEN DB |
Takeyama, Naoshi Browse this author →KAKEN DB |
Yamashita, Norio Browse this author |
Ikeda, Hiroto Browse this author |
Ueyama, Masashi Browse this author |
Fujimi, Satoshi Browse this author |
Gando, Satoshi Browse this author →KAKEN DB |
Issue Date: | 19-Feb-2020 |
Publisher: | Nature Publishing Group |
Journal Title: | Scientific reports |
Volume: | 10 |
Issue: | 1 |
Start Page: | 2983 |
Publisher DOI: | 10.1038/s41598-020-59830-6 |
Abstract: | The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged >= 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p=0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p=0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated. |
Rights: | http://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/79484 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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