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Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke

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Title: Clinical Trials of Stem Cell Therapy for Cerebral Ischemic Stroke
Authors: Kawabori, Masahito Browse this author →KAKEN DB
Shichinohe, Hideo Browse this author →KAKEN DB
Kuroda, Satoshi Browse this author →KAKEN DB
Houkin, Kiyohiro Browse this author →KAKEN DB
Keywords: stem cell
regenerative medicine
ischemic stroke
clinical trials
transplantation
Issue Date: 2020
Publisher: Molecular Diversity Preservation International
Journal Title: International Journal of Molecular Sciences
Volume: 21
Issue: 19
Start Page: 7380
Publisher DOI: 10.3390/ijms21197380
Abstract: Despite recent developments in innovative treatment strategies, stroke remains one of the leading causes of death and disability worldwide. Stem cell therapy is currently attracting much attention due to its potential for exerting significant therapeutic effects on stroke patients. Various types of cells, including bone marrow mononuclear cells, bone marrow/adipose-derived stem/stromal cells, umbilical cord blood cells, neural stem cells, and olfactory ensheathing cells have enhanced neurological outcomes in animal stroke models. These stem cells have also been tested via clinical trials involving stroke patients. In this article, the authors review potential molecular mechanisms underlying neural recovery associated with stem cell treatment, as well as recent advances in stem cell therapy, with particular reference to clinical trials and future prospects for such therapy in treating stroke.
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79552
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川堀 真人

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