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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Environmental Science / Faculty of Environmental Earth Science >
Peer-reviewed Journal Articles, etc >
Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera |
| Authors: | Fathoni, Imam Browse this author | | Petitbois, Julie G. Browse this author | | Alarif, Walied M. Browse this author | | Abdel-Lateff, Ahmed Browse this author | | Al-Lihaibi, Sultan S. Browse this author | | Yoshimura, Erina Browse this author | | Nogata, Yasuyuki Browse this author →KAKEN DB | | Vairappan, Charles S. Browse this author | | Sholikhah, Eti Nurwening Browse this author | | Okino, Tatsufumi Browse this author →KAKEN DB |
| Keywords: | cyanobacteria | | antiplasmodial | | cytotoxic | | antifouling | | Moorea | | Okeania |
| Issue Date: | 1-Sep-2020 |
| Publisher: | MDPI |
| Journal Title: | Molecules |
| Volume: | 25 |
| Issue: | 17 |
| Start Page: | 3986 |
| Publisher DOI: | 10.3390/molecules25173986 |
| Abstract: | Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a MalaysianMoorea bouilloniiand a Red SeaOkeaniasp.: lyngbyabellins G (1), O (2), P (3), H (4), A (7), 27-deoxylyngbyabellin A (5), and homohydroxydolabellin (6). This study indicated that lyngbyabellins displayed cytotoxicity, antimalarial, and antifouling activities. The isolated compounds were tested for cytotoxic effect against human breast cancer cells (MCF7), for antifouling activity againstAmphibalanus amphitritebarnacle larvae, and for antiplasmodial effect towardsPlasmodium falciparum. Lyngbyabellins A and G displayed potent antiplasmodial effect againstPlasmodium, whereas homohydroxydolabellin showed moderate effect. For antifouling activity, the side chain decreases the activity slightly, but the essential feature is the acyclic structure. As previously reported, the acyclic lyngbyabellins are less cytotoxic than the corresponding cyclic ones, and the side chain increases cytotoxicity. This study revealed that lyngbyabellins, despite being cytotoxic agents as previously reported, also exhibit antimalarial and antifouling activities. The unique chemical structures and functionalities of lyngbyabellin play an essential role in their biological activities. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79611 |
| Appears in Collections: | 環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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