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Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera

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Title: Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera
Authors: Fathoni, Imam Browse this author
Petitbois, Julie G. Browse this author
Alarif, Walied M. Browse this author
Abdel-Lateff, Ahmed Browse this author
Al-Lihaibi, Sultan S. Browse this author
Yoshimura, Erina Browse this author
Nogata, Yasuyuki Browse this author →KAKEN DB
Vairappan, Charles S. Browse this author
Sholikhah, Eti Nurwening Browse this author
Okino, Tatsufumi Browse this author →KAKEN DB
Keywords: cyanobacteria
Issue Date: 1-Sep-2020
Publisher: MDPI
Journal Title: Molecules
Volume: 25
Issue: 17
Start Page: 3986
Publisher DOI: 10.3390/molecules25173986
Abstract: Cyanobacteria are reported as rich sources of secondary metabolites that provide biological activities such as enzyme inhibition and cytotoxicity. Ten depsipeptide derivatives (lyngbyabellins) were isolated from a MalaysianMoorea bouilloniiand a Red SeaOkeaniasp.: lyngbyabellins G (1), O (2), P (3), H (4), A (7), 27-deoxylyngbyabellin A (5), and homohydroxydolabellin (6). This study indicated that lyngbyabellins displayed cytotoxicity, antimalarial, and antifouling activities. The isolated compounds were tested for cytotoxic effect against human breast cancer cells (MCF7), for antifouling activity againstAmphibalanus amphitritebarnacle larvae, and for antiplasmodial effect towardsPlasmodium falciparum. Lyngbyabellins A and G displayed potent antiplasmodial effect againstPlasmodium, whereas homohydroxydolabellin showed moderate effect. For antifouling activity, the side chain decreases the activity slightly, but the essential feature is the acyclic structure. As previously reported, the acyclic lyngbyabellins are less cytotoxic than the corresponding cyclic ones, and the side chain increases cytotoxicity. This study revealed that lyngbyabellins, despite being cytotoxic agents as previously reported, also exhibit antimalarial and antifouling activities. The unique chemical structures and functionalities of lyngbyabellin play an essential role in their biological activities.
Type: article
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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