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Gateway reflex : Local neuroimmune interactions that regulate blood vessels

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Title: Gateway reflex : Local neuroimmune interactions that regulate blood vessels
Authors: Kamimura, Daisuke Browse this author →KAKEN DB
Ohki, Takuto Browse this author
Arima, Yasunobu Browse this author →KAKEN DB
Ota, Mitsutoshi Browse this author
Murakami, Masaaki Browse this author →KAKEN DB
Keywords: Blood-brain barrier
Experimental autoimmune encephalomyelitis
Multiple sclerosis
NF-kappa B
Issue Date: Nov-2019
Publisher: Elsevier
Journal Title: Neurochemistry international
Volume: 130
Start Page: 104303
Publisher DOI: 10.1016/j.neuint.2018.09.011
Abstract: Neuroimmunology is a research field that intersects neuroscience and immunology, with the larger aim of gaining significant insights into the pathophysiology of chronic inflammatory diseases such as multiple sclerosis. Conventional studies in this field have so far mainly dealt with immune responses in the nervous system (i.e. neuroinflammation) or systemic immune regulation by the release of glucocorticoids. On the other hand, recently accumulating evidence has indicated bidirectional interactions between specific neural activations and local immune responses. Here we discuss one such local neuroimmune interaction, the gateway reflex. The gateway reflex represents a mechanism that translates specific neural stimulations into local inflammatory outcomes by changing the state of specific blood vessels to allow immune cells to extravasate, thus forming the gateway. Several types of gateway reflex have been identified, and each regulates distinct blood vessels to create gateways for immune cells that induce local inflammation. The gateway reflex represents a novel therapeutic strategy for neuroinflammation and is potentially applicable to other inflammatory diseases in peripheral organs.
Rights: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 村上 正晃

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