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Gateway reflex : Local neuroimmune interactions that regulate blood vessels
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Gateway reflex : Local neuroimmune interactions that regulate blood vessels |
| Authors: | Kamimura, Daisuke Browse this author →KAKEN DB | | Ohki, Takuto Browse this author | | Arima, Yasunobu Browse this author →KAKEN DB | | Ota, Mitsutoshi Browse this author | | Murakami, Masaaki Browse this author →KAKEN DB |
| Keywords: | Blood-brain barrier | | Chemokines | | Experimental autoimmune encephalomyelitis | | Multiple sclerosis | | NF-kappa B |
| Issue Date: | Nov-2019 |
| Publisher: | Elsevier |
| Journal Title: | Neurochemistry international |
| Volume: | 130 |
| Start Page: | 104303 |
| Publisher DOI: | 10.1016/j.neuint.2018.09.011 |
| Abstract: | Neuroimmunology is a research field that intersects neuroscience and immunology, with the larger aim of gaining significant insights into the pathophysiology of chronic inflammatory diseases such as multiple sclerosis. Conventional studies in this field have so far mainly dealt with immune responses in the nervous system (i.e. neuroinflammation) or systemic immune regulation by the release of glucocorticoids. On the other hand, recently accumulating evidence has indicated bidirectional interactions between specific neural activations and local immune responses. Here we discuss one such local neuroimmune interaction, the gateway reflex. The gateway reflex represents a mechanism that translates specific neural stimulations into local inflammatory outcomes by changing the state of specific blood vessels to allow immune cells to extravasate, thus forming the gateway. Several types of gateway reflex have been identified, and each regulates distinct blood vessels to create gateways for immune cells that induce local inflammation. The gateway reflex represents a novel therapeutic strategy for neuroinflammation and is potentially applicable to other inflammatory diseases in peripheral organs. |
| Rights: | © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79650 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 村上 正晃
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