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Green tea consumption and risk of hematologic neoplasms : the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)

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Title: Green tea consumption and risk of hematologic neoplasms : the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
Authors: Takada, Midori Browse this author
Yamagishi, Kazumasa Browse this author →KAKEN DB
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: Epigallocatechin-3-gallate
Hematologic neoplasm
Japan collaborative cohort study for evaluation of cancer risk
Preventive medicine
Green tea
Acute myeloid leukemia
Issue Date: Nov-2019
Publisher: Springer
Journal Title: Cancer causes & control
Volume: 30
Issue: 11
Start Page: 1223
End Page: 1230
Publisher DOI: 10.1007/s10552-019-01220-z
Abstract: Purpose Experimental studies suggested that green tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted. Methods A total of 65,042 individuals aged 40-79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline (1988-1990). Of these, 52,462 individuals living in 24 communities with information on incident hematologic neoplasms available in the cancer registry, who did not have a history of cancer and provided valid information on frequency of green tea consumption, were followed through 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of hematologic neoplasms according to green tea consumption were analyzed. Results The incidence of hematologic neoplasms during a median follow-up of 13.3 years was 323. Compared with the never-drinkers of green tea, the multivariate HRs and 95% CIs for total hematologic neoplasms in green tea drinkers of = 2 cups/day, 3-4 cups/day, and = 5 cups/day were 0.65 (0.42-1.00), 0.73 (0.47-1.13), and 0.63 (0.42-0.96), respectively. The association was more prominent for acute myeloid leukemias and follicular lymphomas. Conclusions The present cohort study suggests a protective effect of green tea against hematologic neoplasms, especially acute myeloid leukemias.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Cancer Causes & Control. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉腰 暁子

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