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Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease

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Title: Clinical factors affecting evoked magnetic fields in patients with Parkinson's disease
Authors: Naganuma, Ryoji Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Takeuchi, Megumi Browse this author
Morishita, Kirari Browse this author
Nakane, Shingo Browse this author
Takase, Ryoken Browse this author
Takahashi-Iwata, Ikuko Browse this author
Matsushima, Masaaki Browse this author
Otsuki, Mika Browse this author →KAKEN DB
Shiraishi, Hideaki Browse this author →KAKEN DB
Sasaki, Hidenao Browse this author →KAKEN DB
Issue Date: 17-Sep-2020
Publisher: PLOS
Journal Title: PLoS ONE
Volume: 15
Issue: 9
Start Page: e0232808
Publisher DOI: 10.1371/journal.pone.0232808
Abstract: Studies on evoked responses in Parkinson's disease (PD) may be useful for elucidating the etiology and quantitative evaluation of PD. However, in previous studies, the association between evoked responses and detailed motor symptoms or cognitive functions has not been clear. This study investigated the characteristics of the visual (VEF), auditory (AEF), and somatosensory (SEF) evoked magnetic fields in patients with Parkinson's disease (PD), and the correlations between evoked fields and the patient's clinical characteristics, motor symptoms, and cognitive functions. Twenty patients with PD and 10 healthy controls (HCs) were recruited as participants. We recorded VEF, AEF, and SEF, collected clinical characteristics, performed physical examinations, and administered 10 cognitive tests. We investigated differences in the latencies of the evoked fields between patients with PD and HCs. We also evaluated the correlation of the latencies with motor symptoms and cognitive functioning. There were significant differences between the two groups in 6 of the cognitive tests, all of which suggested mild cognitive impairment in patients with PD. The latencies of the VEF N75m, P100m, N145m, AEF P50m, P100m, and SEF P60m components were greater in the patients with PD than in the HCs. The latencies mainly correlated with medication and motor symptoms, less so with cognitive tests, with some elements of the correlations remaining significant after Bonferroni correction. In conclusion, the latencies of the VEF, AEF, and SEF were greater in PD patients than in HCs and were mainly correlated with medication and motor symptoms rather than cognitive functioning. Findings from this study suggest that evoked fields may reflect basal ganglia functioning and are candidates for assessing motor symptoms or the therapeutic effects of medication in patients with PD.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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