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Apathy in Alzheimer's Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei

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Title: Apathy in Alzheimer's Disease Correlates with the Dopamine Transporter Level in the Caudate Nuclei
Authors: Udo, Niki Browse this author
Hashimoto, Naoki Browse this author
Toyonaga, Takuya Browse this author
Isoyama, Tomoyuki Browse this author
Oyanagi, Yuka Browse this author
Narita, Hisashi Browse this author →KAKEN DB
Shiga, Tohru Browse this author →KAKEN DB
Nakagawa, Shin Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Alzheimer's disease
Caudate nucleus
Single-photon emission computed tomography
Issue Date: 2020
Publisher: Karger
Journal Title: Dementia and Geriatric Cognitive Disorders Extra
Volume: 10
Issue: 2
Start Page: 86
End Page: 93
Publisher DOI: 10.1159/000509278
Abstract: Introduction:Apathy is a common neuropsychiatric symptom in patients with Alzheimer's disease (AD). The striatal binding potential (BP) of I-123-FP-CIT (N-delta-fluoropropyl-2 beta-carbomethoxy-3 beta-[4-iodophenyl]tropane) single-photon emission computed tomography (SPECT) is correlated with the degree of apathy in patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). This study aimed to determine if dopaminergic activity in the basal ganglia is associated with the development of apathy in AD.Methods:Nineteen subjects with AD were included and underwent I-123-FP-CIT-SPECT. Patients with other types of dementia as a comorbidity, those taking antidepressants, and those with overt parkinsonism were excluded. Apathy was assessed using the Apathy Evaluation Scale Informant-Japanese version (AES-I-J). SPECT images were overlaid with images in striatal regions of interest (ROIs), and the SPECT values in these regions were counted. The relationship between BP values and AES-I-J scores was investigated using Spearman's rank correlation coefficient.Results:Significant inverse correlations were observed between BP values and AES-I-J scores in the left caudate nucleus and there was a marginally significant inverse correlation in the right caudate nucleus.Conclusion:The pathological basis of apathy might be the impairment of the dopaminergic nervous system. Further studies on more subjects with AD, healthy controls, and patients with PD and DLB are needed.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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