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Molecular, antigenic, and pathogenic characterization of H5N8 highly pathogenic avian influenza viruses isolated in the Democratic Republic of Congo in 2017

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79728

Title: Molecular, antigenic, and pathogenic characterization of H5N8 highly pathogenic avian influenza viruses isolated in the Democratic Republic of Congo in 2017
Authors: Twabela, T. Augustin Browse this author
Okamatsu, Masatoshi Browse this author →KAKEN DB
Tshilenge, Georges Mbuyi Browse this author
Mpiana, Serge Browse this author
Masumu, Justin Browse this author
Lam Thanh Nguyen Browse this author
Matsuno, Keita Browse this author →KAKEN DB
Monne, Isabella Browse this author
Zecchin, Bianca Browse this author
Sakoda, Yoshihiro Browse this author →KAKEN DB
Issue Date: 9-Nov-2019
Publisher: Springer
Journal Title: Archives of virology
Volume: 165
Issue: 1
Start Page: 87
End Page: 96
Publisher DOI: 10.1007/s00705-019-04456-x
PMID: 31707455
Abstract: In May 2017, high mortality of chickens and Muscovy ducks due to the H5N8 highly pathogenic avian influenza virus (HPAIV) was reported in the Democratic Republic of Congo (DR Congo). In this study, we assessed the molecular, antigenic, and pathogenic features in poultry of the H5N8 HPAIV from the 2017 Congolese outbreaks. Phylogenetic analysis of the eight viral gene segments revealed that all 12 DR Congo isolates clustered in clade 2.3.4.4B together with other H5N8 HPAIVs isolated in Africa and Eurasia, suggesting a possible common origin of these viruses. Antigenically, a slight difference was observed between the Congolese isolates and a representative virus from group C in the same clade. After intranasal inoculation with a representative DR Congo virus, high pathogenicity was observed in chickens and Muscovy ducks but not in Pekin ducks. Viral replication was higher in chickens than in Muscovy duck and Pekin duck organs; however, neurotropism was pronounced in Muscovy ducks. Our data confirmed the high pathogenicity of the DR Congo virus in chickens and Muscovy ducks, as observed in the field. National awareness and strengthening surveillance in the region are needed to better control HPAIVs.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Archives of virology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00705-019-04456-x
Type: article (author version)
URI: http://hdl.handle.net/2115/79728
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 迫田 義博

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