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Functional decline of the precuneus associated with mild cognitive impairment : Magnetoencephalographic observations

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Title: Functional decline of the precuneus associated with mild cognitive impairment : Magnetoencephalographic observations
Authors: Yokosawa, Koichi Browse this author →KAKEN DB
Kimura, Keisuke Browse this author
Takase, Ryoken Browse this author
Murakami, Yui Browse this author
Boasen, Jared Browse this author →KAKEN DB
Issue Date: 28-Sep-2020
Publisher: PLOS
Journal Title: PLoS ONE
Volume: 15
Issue: 9
Start Page: e0239577
Publisher DOI: 10.1371/journal.pone.0239577
PMID: 32986743
Abstract: Mild Cognitive Impairment (MCI) is a border or precursor state of dementia. To optimize implemented interventions for MCI, it is essential to clarify the underlying neural mechanisms. However, knowledge regarding the brain regions responsible for MCI is still limited. Here, we implemented the Montreal Cognitive Assessment (MoCA) test, a screening tool for MCI, in 20 healthy elderly participants (mean age, 67.5 years), and then recorded magnetoencephalograms (MEG) while they performed a visual sequential memory task. In the task, each participant memorized the four possible directions of seven sequentially presented arrow images. Recall accuracy for beginning items of the memory sequence was significantly positively related with MoCA score. Meanwhile, MEG revealed stronger alpha-band (8-13 Hz) rhythm desynchronization bilaterally in the precuneus (PCu) for higher MoCA (normal) participants. Most importantly, this PCu desynchronization response weakened in correspondence with lower MoCA score during the beginning of sequential memory encoding, a time period that should rely on working memory and be affected by declined cognitive function. Our results suggest that deactivation of the PCu is associated with early MCI, and corroborate pathophysiological findings based on post-mortem tissue which have implicated hypoperfusion of the PCu in early stages of Alzheimer disease. Our results indicate the possibility that cognitive decline can be detected early and non-invasively by monitoring PCu activity with electrophysiological methods.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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