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Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation

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Title: Daurichromenic Acid from the Chinese Traditional Medicinal Plant Rhododendron dauricum Inhibits Sphingomyelin Synthase and A beta Aggregation
Authors: Deepak, Hadya Virupaksha Browse this author
Swamy, Mahadeva M. M. Browse this author
Murai, Yuta Browse this author
Suga, Yoshiko Browse this author
Anetai, Masaki Browse this author
Yo, Takuro Browse this author
Kuragano, Masahiro Browse this author
Uwai, Koji Browse this author
Tokuraku, Kiyotaka Browse this author
Monde, Kenji Browse this author →KAKEN DB
Keywords: daurichromenic acid
sphingomyelin synthase
amyloid β
dual inhibitor
lipid-related disease
Issue Date: Sep-2020
Publisher: MDPI
Journal Title: Molecules
Volume: 25
Issue: 18
Start Page: 4077
Publisher DOI: 10.3390/molecules25184077
Abstract: Species of the genus Rhododendron have been used in traditional Chinese medicine, with the medicinal herb "Manshanfong" used as an expectorant and for the treatment of acute bronchitis. Daurichromenic acid (DCA), a constituent of Rhododendron dauricum, is a meroterpenoid with antibacterial, anti-HIV, and anti-inflammatory activities. However, the mechanisms underlying these pharmacologic activities are poorly understood. To develop new drugs based on DCA, more information is required regarding its interactions with biomolecules. The present study showed that DCA inhibits the activity of the enzyme sphingomyelin synthase, with an IC50 of 4 mu M. The structure-activity relationships between DCA and sphingomyelin synthase were evaluated using derivatives and cyclized hongoquercin A. In addition, DCA was found to inhibit amyloid beta aggregation. These results may help in the design of effective drugs based on DCA.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79844
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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