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Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS

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Title: Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS
Authors: Ishii, Chihiro Browse this author
Nakayama, Shouta M. M. Browse this author
Kataba, Andrew Browse this author
Ikenaka, Yoshinori Browse this author
Saito, Keisuke Browse this author
Watanabe, Yukiko Browse this author
Makino, Yoshiki Browse this author
Matsukawa, Takehisa Browse this author
Kubota, Ayano Browse this author
Yokoyama, Kazuhito Browse this author
Mizukawa, Hazuki Browse this author
Hirata, Takafumi Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Pb accumulation
Trabecular bone
Bone marrow
Tissue correlation
Issue Date: 1-Dec-2018
Publisher: Elsevier
Journal Title: Chemosphere
Volume: 212
Start Page: 994
End Page: 1001
Publisher DOI: 10.1016/j.chemosphere.2018.08.149
Abstract: Lead (Pb) poisoning in raptors and water birds is a serious problem in many countries. However, only a small fraction of Pb poisoning has been detected in birds. Bone specimens may be useful indices of Pb exposure because bones contain similar to 90% of the total Pb body burden. The original purpose of this study was to comprehensively analyze Pb accumulation in various bone types using inductively coupled plasma mass spectrometry (ICP-MS). Since our results showed that Pb accumulation differed greatly depending on bone type, a secondary objective was defined, aiming to investigate the fine Pb distribution and its relation to bone structure and bone marrow by using laser ablation (LA)-ICP-MS. Our findings suggested that bone samples (1) consisting of trabecular tissue and (2) those that contain bone marrow could accumulate high levels of Pb following acute exposure. The shorter turnover time of trabecular bone can cause a rapid accumulation of Pb, and bone marrow may have an important role for internal exposure of Pb to bone tissue. Pb is accumulated in bones via blood flow, and bone marrow receives blood from outside the bones. In conclusion, bone samples provide valuable information on Pb exposure and could be useful to investigate and understand mortalities related to suspected Pb poisoning. (C) 2018 Published by Elsevier Ltd.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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