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Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer

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Title: Association between the use of antibiotics and efficacy of gemcitabine plus nab-paclitaxel in advanced pancreatic cancer
Authors: Nakano, Shintaro Browse this author
Komatsu, Yoshito Browse this author →KAKEN DB
Kawamoto, Yasuyuki Browse this author →KAKEN DB
Saito, Rika Browse this author
Ito, Ken Browse this author
Nakatsumi, Hiroshi Browse this author →KAKEN DB
Yuki, Satoshi Browse this author
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: antibiotics
gemcitabine plus nab-paclitaxel
pancreatic cancer
progression-free survival
retrospective cohort
Issue Date: 25-Sep-2020
Publisher: Lippincott Williams & Wilkins (LWW)
Journal Title: Medicine
Volume: 99
Issue: 39
Publisher DOI: 10.1097/MD.0000000000022250
Abstract: It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP. We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hospital. Ninety-nine patients were eligible for the study. Thirty-seven used antibiotics (U) and 62 did not use antibiotics (NU) during GnP therapy. In the U group, 15 patients used beta-lactam antibiotics, 21 used new quinolones, and 1 used carbapenem. The median progression-free survival was 5.8 and 2.7 months (hazards ratio [HR] .602, 95% confidence interval [CI] .391-.928,P = .022) and the median overall survival was 11.0 and 8.4 months (HR .768, 95% CI .491-1.202,P = .248) in the U and not use antibiotics groups, respectively. Antibiotic use (HR .489, 95% CI .287-.832,P = .008) and locally advanced pancreatic cancer (HR 1.808, 95% CI 1.051-3.112,P = .032) were independent prognostic factors for progression-free survival. Antibiotic use was associated with a higher efficacy of GnP, and therefore, it may be employed as a novel treatment strategy.
Rights: http://creativecommons.org/licenses/by-nc/4.0
Type: article
URI: http://hdl.handle.net/2115/79870
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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