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Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis

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Title: Milk Intake and Stroke Mortality in the Japan Collaborative Cohort Study-A Bayesian Survival Analysis
Authors: Wang, Chaochen Browse this author
Yatsuya, Hiroshi Browse this author →KAKEN DB
Lin, Yingsong Browse this author →KAKEN DB
Sasakabe, Tae Browse this author
Kawai, Sayo Browse this author
Kikuchi, Shogo Browse this author →KAKEN DB
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: milk intake
Bayesian survival anlysis
time-to-event data
JACC study
Issue Date: Sep-2020
Publisher: MDPI
Journal Title: Nutrients
Volume: 12
Issue: 9
Start Page: 2743
Publisher DOI: 10.3390/nu12092743
Abstract: The aim of this study was to further examine the relationship between milk intake and stroke mortality among the Japanese population. We used data from the Japan Collaborative Cohort (JACC) Study (total number of participants = 110,585, age range: 40-79) to estimate the posterior acceleration factors (AF) as well as the hazard ratios (HR) comparing individuals with different milk intake frequencies against those who never consumed milk at the study baseline. These estimations were computed through a series of Bayesian survival models that employed a Markov Chain Monte Carlo simulation process. In total, 100,000 posterior samples were generated separately through four independent chains after model convergency was confirmed. Posterior probabilites that daily milk consumers had lower hazard or delayed mortality from strokes compared to non-consumers was 99.0% and 78.0% for men and women, respectively. Accordingly, the estimated posterior means of AF and HR for daily milk consumers were 0.88 (95% Credible Interval, CrI: 0.81, 0.96) and 0.80 (95% CrI: 0.69, 0.93) for men and 0.97 (95% CrI: 0.88, 1.10) and 0.95 (95% CrI: 0.80, 1.17) for women. In conclusion, data from the JACC study provided strong evidence that daily milk intake among Japanese men was associated with delayed and lower risk of mortality from stroke especially cerebral infarction.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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