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Genomic characterization of human adenovirus type 4 strains isolated worldwide since 1953 identifies two separable phylogroups evolving at different rates from their most recent common ancestor
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| Title: | Genomic characterization of human adenovirus type 4 strains isolated worldwide since 1953 identifies two separable phylogroups evolving at different rates from their most recent common ancestor |
| Authors: | Gonzalez, Gabriel Browse this author | | Bair, Camden R. Browse this author | | Lamson, Daryl M. Browse this author | | Watanabe, Hidemi Browse this author | | Panto, Laura Browse this author | | Carr, Michael J. Browse this author | | Kajon, Adriana E. Browse this author |
| Keywords: | Adenovirus type 4 | | Human mastadenovirus E | | Genetic diversity | | Evolution |
| Issue Date: | Dec-2019 |
| Publisher: | Elsevier |
| Journal Title: | Virology |
| Volume: | 538 |
| Start Page: | 11 |
| End Page: | 23 |
| Publisher DOI: | 10.1016/j.virol.2019.08.028 |
| Abstract: | Species Human mastadenovirus E (HAdV-E) comprises several simian types and a single human type: HAdV-E4, a respiratory and ocular pathogen. RFLP analysis for the characterization of intratypic genetic variability has previously distinguished two HAdV-E4 clusters: prototype (p)-like and a-like. Our analysis of whole genome sequences confirmed two distinct lineages, which we refer to as phylogroups (PGs). PGs I and II comprise the p-and a-like genomes, respectively, and differ significantly in their G + C content (57.7% +/- 0.013 vs 56.3% +/- 0.015). Sequence differences distinguishing the two clades map to several regions of the genome including E3 and ITR. Bayesian analyses showed that the two phylogroups diverged approximately 602 years before the present. A relatively faster evolutionary rate was identified for PG II. Our data provide a rationale for the incorporation of phylogroup identity to HAdV-E4 strain designation to reflect the identified unique genetic characteristics that distinguish PGs I and II. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79879 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: Gabriel Gonzalez
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