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Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone

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Title: Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone
Authors: Hata, Hironobu Browse this author →KAKEN DB
Kitao, Tomoka Browse this author
Sato, Jun Browse this author →KAKEN DB
Asaka, Takuya Browse this author →KAKEN DB
Imamachi, Kenji Browse this author →KAKEN DB
Miyakoshi, Masaaki Browse this author
Hirata, Kenji Browse this author →KAKEN DB
Magota, Keiichi Browse this author →KAKEN DB
Munakata, Yamato Browse this author
Shiga, Tohru Browse this author →KAKEN DB
Yamazaki, Yutaka Browse this author →KAKEN DB
Kitagawa, Yoshimasa Browse this author →KAKEN DB
Issue Date: 15-Oct-2020
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 10
Issue: 1
Start Page: 17461
Publisher DOI: 10.1038/s41598-020-74335-y
Abstract: Effects of long-term bisphosphonate (BP) administration on the metabolism of healthy bone and the concomitant changes in imaging are unclear. Hence, we aimed to retrospectively investigate the effects of long-term BP administration on the intact parietal bone using the standardised uptake value (SUV) derived from single photon emission computed tomography (SPECT). We enrolled 29 patients who had odontogenic infection, osteoporosis, bone metastasis cancer, or rheumatoid arthritis, and classified them into BP-naive: A (14 patients) and BP-treated: B,<4 years (7 patients) and C,<greater than or equal to>4 years (8 patients) groups. We measured the maximum bilateral SUV (SUVmax) of the parietal bone using quantitative bone SPECT software. There were significant differences in the duration of BP administration and SUVmax of the parietal bone among the diseases (P<0.0001 and P=0.0086, respectively). There was a positive correlation between the duration of BP administration and SUVmax of the parietal bone (r(s)=0.65, P=0.0002). The SUVmax was significantly different between A and B (P=0.02) and between A and C (P=0.0024) groups. This is the first report on the correlation between long-term BP administration and the SUVmax of the parietal bone using the quantitative bone SPECT analysis.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/79885
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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