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Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone
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Title: | Quantitative bone single photon emission computed tomography analysis of the effects of duration of bisphosphonate administration on the parietal bone |
Authors: | Hata, Hironobu Browse this author →KAKEN DB | Kitao, Tomoka Browse this author | Sato, Jun Browse this author →KAKEN DB | Asaka, Takuya Browse this author →KAKEN DB | Imamachi, Kenji Browse this author →KAKEN DB | Miyakoshi, Masaaki Browse this author | Hirata, Kenji Browse this author →KAKEN DB | Magota, Keiichi Browse this author →KAKEN DB | Munakata, Yamato Browse this author | Shiga, Tohru Browse this author →KAKEN DB | Yamazaki, Yutaka Browse this author →KAKEN DB | Kitagawa, Yoshimasa Browse this author →KAKEN DB |
Issue Date: | 15-Oct-2020 |
Publisher: | Nature Research |
Journal Title: | Scientific reports |
Volume: | 10 |
Issue: | 1 |
Start Page: | 17461 |
Publisher DOI: | 10.1038/s41598-020-74335-y |
Abstract: | Effects of long-term bisphosphonate (BP) administration on the metabolism of healthy bone and the concomitant changes in imaging are unclear. Hence, we aimed to retrospectively investigate the effects of long-term BP administration on the intact parietal bone using the standardised uptake value (SUV) derived from single photon emission computed tomography (SPECT). We enrolled 29 patients who had odontogenic infection, osteoporosis, bone metastasis cancer, or rheumatoid arthritis, and classified them into BP-naive: A (14 patients) and BP-treated: B,<4 years (7 patients) and C,<greater than or equal to>4 years (8 patients) groups. We measured the maximum bilateral SUV (SUVmax) of the parietal bone using quantitative bone SPECT software. There were significant differences in the duration of BP administration and SUVmax of the parietal bone among the diseases (P<0.0001 and P=0.0086, respectively). There was a positive correlation between the duration of BP administration and SUVmax of the parietal bone (r(s)=0.65, P=0.0002). The SUVmax was significantly different between A and B (P=0.02) and between A and C (P=0.0024) groups. This is the first report on the correlation between long-term BP administration and the SUVmax of the parietal bone using the quantitative bone SPECT analysis. |
Rights: | https://creativecommons.org/licenses/by/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/79885 |
Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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