| Title: | Co-Circulation of Multiple Serotypes of Bluetongue Virus in Zambia |
| Authors: | Chambaro, Herman M. Browse this author |
| Sasaki, Michihito Browse this author |
| Simulundu, Edgar Browse this author |
| Silwamba, Isaac Browse this author |
| Sinkala, Yona Browse this author |
| Gonzalez, Gabriel Browse this author |
| Squarre, David Browse this author |
| Fandamu, Paul Browse this author |
| Lubaba, Caesar H. Browse this author |
| Munyeme, Musso Browse this author |
| Maseko, Alikhadio Browse this author |
| Chimvwele, Choopa Browse this author |
| Mataa, Liywalii Browse this author |
| Mooya, Lynnfield E. Browse this author |
| Mukubesa, Andrew N. Browse this author |
| Harima, Hayato Browse this author |
| Samui, Kenny L. Browse this author |
| Munang'andu, Hetron M. Browse this author |
| Simuunza, Martin Browse this author |
| Nalubamba, King S. Browse this author |
| Qiu, Yongjin Browse this author |
| Carr, Michael J. Browse this author |
| Hall, William W. Browse this author |
| Eshita, Yuki Browse this author |
| Sawa, Hirofumi Browse this author |
| Orba, Yasuko Browse this author →KAKEN DB |
| Keywords: | Reoviridae |
| bluetongue |
| bluetongue virus |
| serotypes |
| topotypes |
| sero-surveillance |
| wild ruminants |
| domestic ruminants |
| Zambia |
| Issue Date: | Sep-2020 |
| Publisher: | MDPI |
| Journal Title: | Viruses-Basel |
| Volume: | 12 |
| Issue: | 9 |
| Start Page: | 963 |
| Publisher DOI: | 10.3390/v12090963 |
| Abstract: | Bluetongue (BT) is an arthropod-borne viral disease of ruminants with serious trade and socio-economic implications. Although the disease has been reported in a number of countries in sub-Saharan Africa, there is currently no information on circulating serotypes and disease distribution in Zambia. Following surveillance for BT in domestic and wild ruminants in Zambia, BT virus (BTV) nucleic acid and antibodies were detected in eight of the 10 provinces of the country. About 40% (87/215) of pooled blood samples from cattle and goats were positive for BTV nucleic acid, while one hartebeest pool (1/43) was positive among wildlife samples. Sequence analysis of segment 2 revealed presence of serotypes 3, 5, 7, 12 and 15, with five nucleotypes (B, E, F, G and J) being identified. Segment 10 phylogeny showed Zambian BTV sequences clustering with Western topotype strains from South Africa, intimating likely transboundary spread of BTV in Southern Africa. Interestingly, two Zambian viruses and one isolate from Israel formed a novel clade, which we designated as Western topotype 4. The high seroprevalence (96.2%) in cattle from Lusaka and Central provinces and co-circulation of multiple serotypes showed that BT is widespread, underscoring the need for prevention and control strategies. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/79919 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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