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Co-Circulation of Multiple Serotypes of Bluetongue Virus in Zambia

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Title: Co-Circulation of Multiple Serotypes of Bluetongue Virus in Zambia
Authors: Chambaro, Herman M. Browse this author
Sasaki, Michihito Browse this author
Simulundu, Edgar Browse this author
Silwamba, Isaac Browse this author
Sinkala, Yona Browse this author
Gonzalez, Gabriel Browse this author
Squarre, David Browse this author
Fandamu, Paul Browse this author
Lubaba, Caesar H. Browse this author
Munyeme, Musso Browse this author
Maseko, Alikhadio Browse this author
Chimvwele, Choopa Browse this author
Mataa, Liywalii Browse this author
Mooya, Lynnfield E. Browse this author
Mukubesa, Andrew N. Browse this author
Harima, Hayato Browse this author
Samui, Kenny L. Browse this author
Munang'andu, Hetron M. Browse this author
Simuunza, Martin Browse this author
Nalubamba, King S. Browse this author
Qiu, Yongjin Browse this author
Carr, Michael J. Browse this author
Hall, William W. Browse this author
Eshita, Yuki Browse this author
Sawa, Hirofumi Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Keywords: Reoviridae
bluetongue virus
wild ruminants
domestic ruminants
Issue Date: Sep-2020
Publisher: MDPI
Journal Title: Viruses-Basel
Volume: 12
Issue: 9
Start Page: 963
Publisher DOI: 10.3390/v12090963
Abstract: Bluetongue (BT) is an arthropod-borne viral disease of ruminants with serious trade and socio-economic implications. Although the disease has been reported in a number of countries in sub-Saharan Africa, there is currently no information on circulating serotypes and disease distribution in Zambia. Following surveillance for BT in domestic and wild ruminants in Zambia, BT virus (BTV) nucleic acid and antibodies were detected in eight of the 10 provinces of the country. About 40% (87/215) of pooled blood samples from cattle and goats were positive for BTV nucleic acid, while one hartebeest pool (1/43) was positive among wildlife samples. Sequence analysis of segment 2 revealed presence of serotypes 3, 5, 7, 12 and 15, with five nucleotypes (B, E, F, G and J) being identified. Segment 10 phylogeny showed Zambian BTV sequences clustering with Western topotype strains from South Africa, intimating likely transboundary spread of BTV in Southern Africa. Interestingly, two Zambian viruses and one isolate from Israel formed a novel clade, which we designated as Western topotype 4. The high seroprevalence (96.2%) in cattle from Lusaka and Central provinces and co-circulation of multiple serotypes showed that BT is widespread, underscoring the need for prevention and control strategies.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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