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Diversity of trypanosomes in wildlife of the Kafue ecosystem, Zambia

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Title: Diversity of trypanosomes in wildlife of the Kafue ecosystem, Zambia
Authors: Squarre, David Browse this author
Hayashida, Kyoko Browse this author
Gaithuma, Alex Browse this author
Chambaro, Herman Browse this author
Kawai, Naoko Browse this author
Moonga, Ladslav Browse this author
Namangala, Boniface Browse this author
Sugimoto, Chihiro Browse this author →KAKEN DB
Yamagishi, Junya Browse this author →KAKEN DB
Keywords: Trypanosoma brucei rhodesiense
Kafue national park
Issue Date: Aug-2020
Publisher: Elsevier
Journal Title: International journal for parasitology-parasites and wildlife
Volume: 12
Start Page: 34
End Page: 41
Publisher DOI: 10.1016/j.ijppaw.2020.04.005
Abstract: The Kafue ecosystem is a vast conservation protected area comprising the Kafue National Park (KNP) and the Game Management Areas (GMA) that act as a buffer around the national park. The KNP has been neglected as a potential foci for rhodesiense sleeping sickness despite the widespread presence of the tsetse vector and abundant wildlife reservoirs. The aim of this study was to generate information on circulating trypanosomes and their eminent threat/risk to public health and livestock production of a steadily growing human and livestock population surrounding the park. We detected various trypanosomes circulating in different mammalian wildlife species in KNP in Zambia by applying a high throughput ITS1-polymerase chain reaction (PCR)/nanopore sequencing method in combination with serum resistant associated-PCR/Sanger sequencing method. The prevalence rates of trypanosomes in hartebeest, sable antelope, buffalo, warthog, impala and lechwe were 6.4%, 37.2%, 13.2%, 11.8%, 2.8% and 11.1%, respectively. A total of six trypanosomes species or subspecies were detected in the wildlife examined, including Trypanosoma brucei brucei, T. godfreyi, T. congolense, T. simiae and T. theileri. Importantly we detected human infective T. b. rhodesiense in buffalo and sable antelope with a prevalence of 9.4% and 12.5%, respectively. In addition, T. b. rhodesiense was found in the only vervet monkey analyzed. The study thus reaffirmed that the Kafue ecosystem is a genuine neglected and re-emerging foci for human African trypanosomiasis. This is the first assessment of the trypanosome diversity circulating in free-ranging wildlife of the KNP.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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