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Blood-brain barrier permeability analysis of plant ceramides

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Title: Blood-brain barrier permeability analysis of plant ceramides
Authors: Eguchi, Koichi Browse this author
Mikami, Daisuke Browse this author
Sun, Hui Browse this author
Tsumita, Takuya Browse this author
Takahashi, Kaori Browse this author
Mukai, Katsuyuki Browse this author
Yuyama, Kohei Browse this author →KAKEN DB
Igarashi, Yasuyuki Browse this author
Issue Date: 2-Nov-2020
Publisher: PLOS
Journal Title: PLoS ONE
Volume: 15
Issue: 11
Start Page: e0241640
Publisher DOI: 10.1371/journal.pone.0241640
Abstract: Ceramides, a type of sphingolipid, are cell membrane components and lipid mediators that modulate a variety of cell functions. In plants, ceramides are mostly present in a glucosylated glucosylceramide (GlcCer) form. We previously showed that oral administration of konjac-derived GlcCer to a mouse model of Alzheimer's disease reduced brain amyloid-beta and amyloid plaques. Dietary plant GlcCer compounds are absorbed as ceramides, but it is unclear whether they can cross the blood-brain barrier (BBB). Herein, we evaluated the BBB permeability of synthetic plant-type ceramides (4, 8-sphingadienine, d18:2) using mouse and BBB cell culture models, and found that they could permeate the BBB both in vivo and in vitro. In addition, administrated ceramides were partially metabolized to other sphingolipid species, namely sphingomyelin (SM) and GlcCer, while crossing the BBB. Thus, plant ceramides can cross the BBB, suggesting that ceramides and their metabolites might affect brain functions.
Type: article
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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