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Hokkaido University Collection of Scholarly and Academic Papers >
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Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy
| Title: | Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy |
| Authors: | Ishigaki, Takahiro Browse this author | | Shingu, Yasushige Browse this author →KAKEN DB | | Katoh, Nobuyasu Browse this author | | Wakasa, Satoru Browse this author →KAKEN DB | | Katoh, Hiroki Browse this author | | Ooka, Tomonori Browse this author →KAKEN DB | | Kubota, Suguru Browse this author →KAKEN DB | | Matsui, Yoshiro Browse this author →KAKEN DB |
| Keywords: | Mitral regurgitation | | Dilated cardiomyopathy | | Preload recruitable stroke work relationship |
| Issue Date: | Jan-2020 |
| Publisher: | Springer |
| Journal Title: | General Thoracic and Cardiovascular Surgery |
| Volume: | 68 |
| Start Page: | 30 |
| End Page: | 37 |
| Publisher DOI: | 10.1007/s11748-019-01164-w |
| Abstract: | Objectives: The slope in the preload recruitable stroke work relationship is a highly linear, load-insensitive contractile parameter. However, the perioperative change of the slope has not been reported before. We examined the perioperative slope from a steady-state single beat in patients with functional mitral regurgitation and assessed the correlation with brain natriuretic peptide (BNP) levels. Methods: The study included 16 patients with non-ischemic dilated cardiomyopathy and refractory heart failure: 10 patients underwent mitral valve plasty and left ventricular plasty (MVP + LVP group) and 6 patients who underwent mitral valve replacement and papillary muscle tugging approximation (MVR + PMTA group). The left ventricular ejection fraction was assessed by the modified Simpson method; the slope was assessed by the single-beat technique using transthoracic echocardiography. BNP levels were measured by chemiluminescent immunoassay. Results: The left ventricular ejection fraction and slope did not significantly change from pre- to early post-surgery in the MVP + LVP group. Both the left ventricular ejection fraction and slope significantly increased 6 months after surgery in the MVR + PMTA group. Postoperative BNP level was low in the MVR + PMTA group. While the postoperative left ventricular ejection fraction did not correlate with BNP levels, the postoperative slope significantly correlated with BNP level after surgery in the MVP + LVP group and in the total functional mitral regurgitation group. Conclusions: The change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction. |
| Rights: | This is a post-peer-review, pre-copyedit version of an article published in General thoracic and cardiovascular surgery. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11748-019-01164-w |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/80089 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 新宮 康栄
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