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Computed diffusion-weighted imaging for differentiating synovial proliferation from joint effusion in hand arthritis

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/80096

Title: Computed diffusion-weighted imaging for differentiating synovial proliferation from joint effusion in hand arthritis
Authors: Tanaka, Yuki Browse this author →KAKEN DB
Fujimori, Motoshi Browse this author
Murakami, Koichi Browse this author
Sugimori, Hiroyuki Browse this author →KAKEN DB
Oki, Nozomi Browse this author
Aoki, Takatoshi Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Keywords: Arthritis
Synovial proliferation
MRI
Computed diffusion-weighted imaging
Issue Date: Dec-2019
Publisher: Springer
Journal Title: Rheumatology international
Volume: 39
Issue: 12
Start Page: 2111
End Page: 2118
Publisher DOI: 10.1007/s00296-019-04425-2
PMID: 31455985
Abstract: The objective of this study is to investigate computed DWI (cDWI) as an alternative method to contrast-enhanced MRI in comparison with directory measured DWI (mDWI) and apparent diffusion coefficient (ADC) for differentiating synovial proliferation from joint effusion. Nine patients suspected with RA (5 women) were included in this study. A radiologist identified region of interest (ROI) based on STIR, and evaluated using a 5-point grading scale of 0 (fluid) to 4 (synovial proliferation) according to the degree of contrast enhancement within the ROI. cDWI was synthesized for b values from 1000 to 2000 at 200 s/mm(2) intervals using the combination of b values at mDWI. In addition to ADC values, contrast ratios were calculated using signal intensity for each ROI on the mDWI and cDWI. Visual assessment by a radiologist was conducted between pairs of STIR image and mDWI or cDWI. ROI grades were most significantly correlated with cDWI(2000) based on b values of 400-1000 s/mm(2) (r(s) = 0.405, p < 0.01). The area under the curve of cDWI(2000) based on b values of 400-1000 s/mm(2) (0.762) was larger than that of ADC values (0.570-0.608) when comparing low versus high contrast enhancement grades. Both cDWI(1800) (200-1000) and cDWI(2000) (400-1000) demonstrated high sensitivity and specificity in visual assessment (84.6% and 66.7%, respectively). The cDWI(2000) based on b values of 400-1000 s/mm(2) may be useful for noninvasive differentiation of synovial proliferation from joint effusion in hand arthritis.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Rheumatology international. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00296-019-04425-2.
Type: article (author version)
URI: http://hdl.handle.net/2115/80096
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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