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Age-related glomerular lesions with albuminuria in male cotton rats

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Title: Age-related glomerular lesions with albuminuria in male cotton rats
Authors: Ichii, Osamu Browse this author →KAKEN DB
Nakamura, Teppei Browse this author
Irie, Takao Browse this author
Otani, Yuki Browse this author
Hosotani, Marina Browse this author
Masum, Md Abdul Browse this author
Islam, Rashedul Md Browse this author
Horino, Taro Browse this author
Sunden, Yuji Browse this author
Elewa, Yaser Hosny Ali Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: Cotton rats
Glomerular basement membrane
Issue Date: Jan-2020
Publisher: Springer
Journal Title: Histochemistry and Cell Biology
Volume: 153
Issue: 1
Start Page: 27
End Page: 36
Publisher DOI: 10.1007/s00418-019-01824-1
Abstract: The increased prevalence of aging-related chronic kidney disease (CKD) among humans is a problem worldwide. Aged cotton rats (Sigmodon hispidus) are considered novel model animals for studying CKD, especially as the females develop severe tubulointerstitial lesions with anemia. To investigate the renal pathologic features in aged male cotton rats and their characteristic glomerular injuries, the animals were divided into young, adult, old-aged, and advanced-aged groups (1-4, 5-8, 9-12, and 13-17 months, respectively) and pathologically analyzed. Anemia and renal dysfunction, as indicated by hematologic and serologic parameters, were significantly milder in the advanced-aged males than in the old-aged females. The males had increased urinary albumin-to-creatinine ratios from the old-age period, with the advanced-aged males having significantly higher levels than those in the old-aged females and young males. The old-aged females did not show clear glomerular injuries, whereas the advanced-aged males showed membranous lesions characterized by irregular and thickened glomerular basement membranes (GBMs). Characteristically, several large-sized projections from the GBM toward the podocytes were observed by microscopy, and podocytes covering these projections effaced their foot processes. The advanced-aged males showed aging-related IgG immune-complex depositions in the paramesangial regions and along the GBM. Furthermore, the positive reaction for podocin (a podocyte molecule) was granulated along the GBM. Thus, we clarified the albuminuria associated with altered glomerular structures in advanced-aged cotton rats, and that these phenotypes were closely associated with aging. These data help to clarify the aging-related pathogenesis of glomerular injury.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Histochemistry and Cell Biology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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