| Title: | Lewy pathology of the esophagus correlates with the progression of Lewy body disease : a Japanese cohort study of autopsy cases |
| Authors: | Tanei, Zen-ichi Browse this author →KAKEN DB |
| Saito, Yuko Browse this author |
| Ito, Shinji Browse this author |
| Matsubara, Tomoyasu Browse this author |
| Motoda, Atsuko Browse this author |
| Yamazaki, Mikihiro Browse this author |
| Sakashita, Yasuhiro Browse this author |
| Kawakami, Ito Browse this author |
| Ikemura, Masako Browse this author |
| Tanaka, Shinya Browse this author →KAKEN DB |
| Sengoku, Renpei Browse this author |
| Arai, Tomio Browse this author |
| Murayama, Shigeo Browse this author |
| Keywords: | Lewy body disease |
| Parkinson’s disease |
| α-Synuclein |
| Esophagus |
| Enteric nervous system |
| Peripheral nervous system |
| Issue Date: | Jan-2021 |
| Publisher: | Springer |
| Journal Title: | Acta Neuropathologica |
| Volume: | 141 |
| Start Page: | 25 |
| End Page: | 37 |
| Publisher DOI: | 10.1007/s00401-020-02233-8 |
| Abstract: | Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson's disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by non-motor symptoms (NMSs) including gastrointestinal dysfunctions such as constipation. Its relationship to Lewy body-related alpha-synucleinopathy (Lewy pathology) of the enteric nervous system (ENS) is attracting attention because it can precede the motor symptoms. To clarify the role of ENS Lewy pathology in disease progression, we performed a clinicopathological study using the Brain Bank for Aging Research in Japan. Five-hundred and eighteen cases were enrolled in the study. Lewy pathology of the CNS and PNS, including the lower esophagus as a representative of the ENS, was examined via autopsy findings. Results showed that one-third of older people (178 cases, 34%) exhibited Lewy pathology, of which 78 cases (43.8%) exhibited the pathology in the esophagus. In the esophageal wall, Auerbach's plexus (41.6%) was most susceptible to the pathology, followed by the adventitia (33.1%) and Meissner's plexus (14.6%). Lewy pathology of the esophagus was significantly associated with autonomic failures such as constipation (p < 0.0001) and among PNS regions, correlated the most with LBD progression (r = 0.95, p < 0.05). These findings suggest that the propagation of esophageal Lewy pathology is a predictive factor of LBD. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80119 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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