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Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)

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Title: Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)
Authors: Khidkhan, Kraisiri Browse this author
Mizukawa, Hazuki Browse this author →KAKEN DB
Ikenaka, Yoshinori Browse this author →KAKEN DB
Nakayama, Shouta M. M. Browse this author →KAKEN DB
Nomiyama, Kei Browse this author →KAKEN DB
Yokoyama, Nozomu Browse this author
Ichii, Osamu Browse this author →KAKEN DB
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Tanabe, Shinsuke Browse this author →KAKEN DB
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: BDE-209
chronic exposure
cytochrome P450
mRNA expression
Issue Date: 31-Jul-2020
Publisher: 公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science)
Journal Title: Journal of veterinary medical science
Volume: 82
Issue: 7
Start Page: 978
End Page: 982
Publisher DOI: 10.1292/jvms.20-0140
Abstract: The knowledge of cytochrome P450 (CYP) expression involved in chemical exposure are necessary in clinical applications for the medication and prediction of adverse effects. The aim of this study was to evaluate the mRNA expression of CYP1-CYP3 families in cats exposed to BDE-209 for one year. All selected CYP isoforms showed no significant difference in mRNA expressions between control and exposure groups, however, CYP3A12 and CYP3A131 revealed tend to be two times higher in the exposure group compared to control group. The present results indicate that the chronic exposure of BDE209 could not alter CYP expression in the liver of cats. This result considered caused by the deficiency of CYP2B subfamily which is major metabolism enzyme of polybrominated diphenyl ethers ( PBDEs) in cat.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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