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Hokkaido University Collection of Scholarly and Academic Papers >
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Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage
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| Title: | Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage |
| Authors: | Shimohata, Nobuyuki Browse this author | | Echigo, Ryosuke Browse this author | | Karatsu, Kensuke Browse this author | | Uchikawa, Saori Browse this author | | Suzuki, Shigeki Browse this author | | Chung, Ung-il Browse this author | | Sasaki, Nobuo Browse this author | | Mochizuki, Manabu Browse this author |
| Keywords: | blood clotting | | coagulation | | fibrinolysis | | subarachnoid hemorrhage | | trehalose |
| Issue Date: | May-2020 |
| Publisher: | 公益社団法人 日本獣医学会 (The Japanese Society of Veterinary Science) |
| Journal Title: | Journal of veterinary medical science |
| Volume: | 82 |
| Issue: | 5 |
| Start Page: | 566 |
| End Page: | 570 |
| Publisher DOI: | 10.1292/jvms.19-0201 |
| Abstract: | Subarachnoid hemorrhage (SAH) frequently results in several serious complications, such as cerebral vasospasm. We previously reported the effect of trehalose on vasospasm, inflammatory responses, and lipid peroxidation induced by blood exposure. Herein, to further elucidate the mechanism of action of trehalose, we investigated whether or not post-administration of trehalose can directly influence blood clotting in the cistern. As a result of trehalose injection after the onset of experimental SAH, blood clotting around the basilar artery was clearly inhibited. We also found that trehalose positively impacted coagulation and fibrinolysis parameters in rat, rabbit and human plasma in vitro. These findings suggest that trehalose has suppressive effects on blood clotting in addition to vasospasm, inflammatory responses, and lipid peroxidation after SAH. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80175 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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