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Quantitative analysis of treatments using real-time image gated spot-scanning with synchrotron-based proton beam therapy system log data

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Title: Quantitative analysis of treatments using real-time image gated spot-scanning with synchrotron-based proton beam therapy system log data
Authors: Yoshimura, Takaaki Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Hashimoto, Takayuki Browse this author →KAKEN DB
Nishioka, Kentaro Browse this author →KAKEN DB
Katoh, Norio Browse this author →KAKEN DB
Taguchi, Hiroshi Browse this author →KAKEN DB
Yasuda, Koichi Browse this author →KAKEN DB
Matsuura, Taeko Browse this author →KAKEN DB
Takao, Seishin Browse this author →KAKEN DB
Tamura, Masaya Browse this author →KAKEN DB
Tanaka, Sodai Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Matsuo, Yuto Browse this author
Tamura, Hiroshi Browse this author
Horita, Kenji Browse this author
Umegaki, Kikuo Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: spot‐scanning proton beam therapy
organ motion
beam delivery efficiency
treatment time
Issue Date: 28-Dec-2020
Publisher: John Wiley & Sons
Journal Title: Journal of applied clinical medical physics
Volume: 21
Issue: 12
Start Page: 10
End Page: 19
Publisher DOI: 10.1002/acm2.13029
Abstract: A synchrotron-based real-time image gated spot-scanning proton beam therapy (RGPT) system with inserted fiducial markers can irradiate a moving tumor with high accuracy. As gated treatments increase the beam delivery time, this study aimed to investigate the frequency of intra-field adjustments corresponding to the baseline shift or drift and the beam delivery efficiency of a synchrotron-based RGPT system. Data from 118 patients corresponding to 127 treatment plans and 2810 sessions between October 2016 and March 2019 were collected. We quantitatively analyzed the proton beam delivery time, the difference between the ideal beam delivery time based on a simulated synchrotron magnetic excitation pattern and the actual treatment beam delivery time, frequency corresponding to the baseline shift or drift, and the gating efficiency of the synchrotron-based RGPT system according to the proton beam delivery machine log data. The mean actual beam delivery time was 7.1 min, and the simulated beam delivery time in an ideal environment with the same treatment plan was 2.9 min. The average difference between the actual and simulated beam delivery time per session was 4.3 min. The average frequency of intra-field adjustments corresponding to baseline shift or drift and beam delivery efficiency were 21.7% and 61.8%, respectively. Based on our clinical experience with a synchrotron-based RGPT system, we determined the frequency corresponding to baseline shift or drift and the beam delivery efficiency using the beam delivery machine log data. To maintain treatment accuracy within +/- 2.0 mm, intra-field adjustments corresponding to baseline shift or drift were required in approximately 20% of cases. Further improvements in beam delivery efficiency may be realized by shortening the beam delivery time.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/80242
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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