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Alcohol Consumption and Risk of Gastric Cancer : The Japan Collaborative Cohort Study

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Title: Alcohol Consumption and Risk of Gastric Cancer : The Japan Collaborative Cohort Study
Authors: Li, Yuting Browse this author
Eshak, Ehab S. Browse this author
Kokoro, Shirai Browse this author →KAKEN DB
Liu, Keyang Browse this author
Dong, J. Y. Browse this author
Iso, Hiroyasu Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: gastric cancer
JACC study
Issue Date: Jan-2021
Publisher: 日本疫学会(Japan Epidemiological Association)JEA
Journal Title: Journal of epidemiology
Volume: 31
Issue: 1
Start Page: 30
End Page: 36
Publisher DOI: 10.2188/jea.JE20190304
Abstract: Background: Alcohol consumption is a potential risk factor for gastric cancer. However, findings from cohort studies that examined the relationship between alcohol consumption and gastric cancer risk among Japanese population are not conclusive. Methods: A total of 54,682 Japanese men and women participating in the Japan Collaborative Cohort study completed a questionnaire, including alcohol consumption information. The Cox proportional hazard model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a median 13.4-year follow-up, we documented 801 men and 466 women incident cases of gastric cancer. Alcohol consumption was associated with increased risk of gastric cancer among men (HRs in ex-drinkers and current alcohol consumption of <23 g, 23-<46 g. 46-<69 g, and >= 69 g/d categories versus never drinkers were 1.82; 95% CI. 1.38-2.42. 1.41; 95% CI, 1.10-1.80, 1.47; 95% CI, 1.17-1.85, 1.88; 95% CI, 1.48-2.38, and 1.85; 95% CI, 1.35-2.53, respectively, and that for 10g increment of alcohol consumption after excluding ex-drinkers was 1.07; 95% CI, 1.04-1.10). The association in men was observed for cardia and non-cardia gastric cancer (HRs in the highest alcohol consumption category versus never drinkers were 9.96; 95% CI, 2.22-44.67 for cardia cancer and 2.40: 95% CI, 1.64-3.52 for non-cardia cancer). However, no such trend was observed in women. Conclusions: Alcohol consumption is associated with increased risk of gastric cancer among Japanese men, regardless of anatomical subsite of the cancer.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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