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Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal

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Title: Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal
Authors: Oiwa, Yuki Browse this author
Oka, Kaori Browse this author
Yasui, Hironobu Browse this author
Higashikawa, Kei Browse this author
Bono, Hidemasa Browse this author
Kawamura, Yoshimi Browse this author
Miyawaki, Shingo Browse this author
Watarai, Akiyuki Browse this author
Kikusui, Takefumi Browse this author
Shimizu, Atsushi Browse this author
Okano, Hideyuki Browse this author
Kuge, Yuji Browse this author
Kimura, Kazuhiro Browse this author →KAKEN DB
Okamatsu-Ogura, Yuko Browse this author →KAKEN DB
Miura, Kyoko Browse this author
Issue Date: 10-Nov-2020
Publisher: Nature Research
Journal Title: Scientific reports
Volume: 10
Issue: 1
Start Page: 19488
Publisher DOI: 10.1038/s41598-020-74929-6
Abstract: The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold and some non-cold environments. Previous studies suggest that NMR-BAT induces thermogenesis by cold exposure. However, detailed NMR-BAT characteristics and whether NMR-BAT thermogenesis occurs in non-cold environments are unknown. Here, we show beta-3 adrenergic receptor (ADRB3)-dependent thermogenic potential of NMR-BAT, which contributes to thermogenesis in the isolated queen in non-cold environments (30 degrees C). NMR-BAT expressed several brown adipocyte marker genes and showed noradrenaline-dependent thermogenic activity in vitro and in vivo. Although our ADRB3 inhibition experiments revealed that NMR-BAT thermogenesis slightly delays the decrease in body temperature in a cold environment (20 degrees C), it was insufficient to prevent the decrease in the body temperatures. Even at 30 degrees C, NMRs are known to prevent the decrease of and maintain their body temperature by heat-sharing behaviors within the colony. However, isolated NMRs maintained their body temperature at the same level as when they are in the colony. Interestingly, we found that queens, but not subordinates, induce BAT thermogenesis in this condition. Our research provides novel insights into NMR thermoregulation.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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