| Title: | Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal |
| Authors: | Oiwa, Yuki Browse this author |
| Oka, Kaori Browse this author |
| Yasui, Hironobu Browse this author |
| Higashikawa, Kei Browse this author |
| Bono, Hidemasa Browse this author |
| Kawamura, Yoshimi Browse this author |
| Miyawaki, Shingo Browse this author |
| Watarai, Akiyuki Browse this author |
| Kikusui, Takefumi Browse this author |
| Shimizu, Atsushi Browse this author |
| Okano, Hideyuki Browse this author |
| Kuge, Yuji Browse this author |
| Kimura, Kazuhiro Browse this author →KAKEN DB |
| Okamatsu-Ogura, Yuko Browse this author →KAKEN DB |
| Miura, Kyoko Browse this author |
| Issue Date: | 10-Nov-2020 |
| Publisher: | Nature Research |
| Journal Title: | Scientific reports |
| Volume: | 10 |
| Issue: | 1 |
| Start Page: | 19488 |
| Publisher DOI: | 10.1038/s41598-020-74929-6 |
| Abstract: | The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold and some non-cold environments. Previous studies suggest that NMR-BAT induces thermogenesis by cold exposure. However, detailed NMR-BAT characteristics and whether NMR-BAT thermogenesis occurs in non-cold environments are unknown. Here, we show beta-3 adrenergic receptor (ADRB3)-dependent thermogenic potential of NMR-BAT, which contributes to thermogenesis in the isolated queen in non-cold environments (30 degrees C). NMR-BAT expressed several brown adipocyte marker genes and showed noradrenaline-dependent thermogenic activity in vitro and in vivo. Although our ADRB3 inhibition experiments revealed that NMR-BAT thermogenesis slightly delays the decrease in body temperature in a cold environment (20 degrees C), it was insufficient to prevent the decrease in the body temperatures. Even at 30 degrees C, NMRs are known to prevent the decrease of and maintain their body temperature by heat-sharing behaviors within the colony. However, isolated NMRs maintained their body temperature at the same level as when they are in the colony. Interestingly, we found that queens, but not subordinates, induce BAT thermogenesis in this condition. Our research provides novel insights into NMR thermoregulation. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80298 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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