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The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis

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Title: The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis
Authors: Sajiki, Yamato Browse this author
Konnai, Satoru Browse this author →KAKEN DB
Goto, Shinya Browse this author
Okagawa, Tomohiro Browse this author →KAKEN DB
Ohira, Kosuke Browse this author
Shimakura, Honami Browse this author
Maekawa, Naoya Browse this author →KAKEN DB
Gondaira, Satoshi Browse this author
Higuchi, Hidetoshi Browse this author
Tajima, Motoshi Browse this author
Hirano, Yuki Browse this author
Kohara, Junko Browse this author
Murata, Shiro Browse this author →KAKEN DB
Ohashi, Kazuhiko Browse this author →KAKEN DB
Keywords: TGF-β
1
Mycoplasma bovis
regulatory T cell
immunosuppression
cattle
Issue Date: 2-Dec-2020
Publisher: Frontiers Media
Journal Title: Frontiers in veterinary science
Volume: 7
Start Page: 609443
Publisher DOI: 10.3389/fvets.2020.609443
Abstract: Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-beta and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4(+)CD25(high)Foxp3(+) T cells, was increased in M. bovis-infected cattle. Additionally, the plasma of M. bovis-infected cattle contained the high concentrations of TGF-beta 1, and M. bovis infection induced TGF-beta 1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-beta 1 on bovine immune cells. Treatment with TGF-beta 1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro. These results suggest that the increase in Tregs and TGF-beta 1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M. bovis infection.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/80300
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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