| Title: | The Suppression of Th1 Response by Inducing TGF-beta 1 From Regulatory T Cells in Bovine Mycoplasmosis |
| Authors: | Sajiki, Yamato Browse this author |
| Konnai, Satoru Browse this author →KAKEN DB |
| Goto, Shinya Browse this author |
| Okagawa, Tomohiro Browse this author →KAKEN DB |
| Ohira, Kosuke Browse this author |
| Shimakura, Honami Browse this author |
| Maekawa, Naoya Browse this author →KAKEN DB |
| Gondaira, Satoshi Browse this author |
| Higuchi, Hidetoshi Browse this author |
| Tajima, Motoshi Browse this author |
| Hirano, Yuki Browse this author |
| Kohara, Junko Browse this author |
| Murata, Shiro Browse this author →KAKEN DB |
| Ohashi, Kazuhiko Browse this author →KAKEN DB |
| Keywords: | TGF-β |
| 1 |
| Mycoplasma bovis |
| regulatory T cell |
| immunosuppression |
| cattle |
| Issue Date: | 2-Dec-2020 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in veterinary science |
| Volume: | 7 |
| Start Page: | 609443 |
| Publisher DOI: | 10.3389/fvets.2020.609443 |
| Abstract: | Regulatory T cells (Tregs) regulate immune responses and maintain host immune homeostasis. Tregs contribute to the disease progression of several chronic infections by oversuppressing immune responses via the secretion of immunosuppressive cytokines, such as transforming growth factor (TGF)-beta and interleukin-10. In the present study, we examined the association of Tregs with Mycoplasma bovis infection, in which immunosuppression is frequently observed. Compared with uninfected cattle, the percentage of Tregs, CD4(+)CD25(high)Foxp3(+) T cells, was increased in M. bovis-infected cattle. Additionally, the plasma of M. bovis-infected cattle contained the high concentrations of TGF-beta 1, and M. bovis infection induced TGF-beta 1 production from bovine immune cells in in vitro cultures. Finally, we analyzed the immunosuppressive effects of TGF-beta 1 on bovine immune cells. Treatment with TGF-beta 1 significantly decreased the expression of CD69, an activation marker, in T cells, and Th1 cytokine production in vitro. These results suggest that the increase in Tregs and TGF-beta 1 secretion could be one of the immunosuppressive mechanisms and that lead to increased susceptibility to other infections in terms of exacerbation of disease during M. bovis infection. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80300 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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