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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Evaluation of antibacterial and cytocompatible properties of multiple-ion releasing zinc-fluoride glass nanoparticles
| Title: | Evaluation of antibacterial and cytocompatible properties of multiple-ion releasing zinc-fluoride glass nanoparticles |
| Authors: | NISHIDA, Erika Browse this author →KAKEN DB | | MIYAJI, Hirofumi Browse this author →KAKEN DB | | SHITOMI, Kanako Browse this author →KAKEN DB | | SUGAYA, Tsutomu Browse this author →KAKEN DB | | AKASAKA, Tsukasa Browse this author →KAKEN DB |
| Keywords: | Actinomyces naeslundii | | Biocompatibility | | Dentin | | Streptococcus mutans | | Zinc-fluoride glass nanoparticles |
| Issue Date: | 25-Jan-2021 |
| Publisher: | Japanese Society for Dental Materials and Devices |
| Journal Title: | Dental Materials Journal |
| Volume: | 40 |
| Issue: | 1 |
| Start Page: | 157 |
| End Page: | 164 |
| Publisher DOI: | 10.4012/dmj.2019-176 |
| PMID: | 32999216 |
| Abstract: | Zinc-fluoride glass nanoparticles (Zinc-F) release several ions, such as fluoride, zinc and calcium ions, through acid-base reactions. The aim of this study was to evaluate the antibacterial and cytotoxic properties of Zinc-F. Antibacterial tests showed that a Zinc-F eluting solution significantly reduced the turbidity and colony-forming units of Streptococcus mutans and Actinomyces naeslundii, compared to that of calcium-fluoroaluminosilicate glass nanoparticles without zinc ions. In live/dead staining, Zinc-F eluate significantly decreased green-stained bacterial cells, indicating live cells, compared with the control (no application). Human dentin coated with Zinc-F showed suppressed S. mutans and A. naeslundii biofilm formation. Additionally, Zinc-F eluate showed low cytotoxic effects in osteoblastic and fibroblastic cells. Therefore, our findings suggested that Zinc-F exhibits antibacterial and biocompatible properties through multiple-ion release. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80367 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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