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CD133 and epithelial cell adhesion molecule expressions in the cholangiocarcinoma component are prognostic factors for combined hepatocellular cholangiocarcinoma

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Title: CD133 and epithelial cell adhesion molecule expressions in the cholangiocarcinoma component are prognostic factors for combined hepatocellular cholangiocarcinoma
Authors: Wakizaka, Kazuki Browse this author
Yokoo, Hideki Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Kakisaka, Tatsuhiko Browse this author →KAKEN DB
Ohira, Masafumi Browse this author
Tani, Michio Browse this author
Kato, Koichi Browse this author
Fujii, Yuki Browse this author
Sugiyama, Ko Browse this author
Nagatsu, Akihisa Browse this author
Shimada, Shingo Browse this author
Orimo, Tatsuya Browse this author
Kamachi, Hirofumi Browse this author →KAKEN DB
Matsuoka, Ryosuke Browse this author
Taketomi, Akinobu Browse this author →KAKEN DB
Keywords: cancer stem cells
combined hepatocellular cholangiocarcinoma
epithelial cell adhesion molecule
Issue Date: 13-Feb-2020
Publisher: John Wiley & Sons
Journal Title: Hepatology Research
Volume: 50
Issue: 2
Start Page: 258
End Page: 267
Publisher DOI: 10.1111/hepr.13443
Abstract: Aim A new classification of combined hepatocellular cholangiocarcinoma (CHC) was recently reported. Cancer stem cells have been associated with CHC carcinogenesis. This study examined the association of cancer stem cell marker expression and prognosis in CHC classified using the new classification. Methods We enrolled 26 CHC patients and classified them according to the new classification. We evaluated the expression of cancer stem cell markers (CD56, CD133, and epithelial cell adhesion molecule [EpCAM]) by immunohistochemical staining in each component. We analyzed the association between expressions and prognosis. Results Seven cases were hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) (cHCC-CCA), 12 were HCC and intermediate cell carcinoma (HCC-INT), and seven were intermediate cell carcinoma (INT). The CD133-positive rate tended to be higher in the CCA (42.9%) and INT component (50.0%) than the HCC component (14.3%) in cHCC-CCA. In HCC-INT, the CD133-positive rate in the INT component (83.3%) was significantly higher than the HCC component (8.3%; P = 0.001). For EpCAM, the positive rate in the CCA component (71.4%) and INT component (50.0%) tended to be higher than the HCC component (14.3%) in cHCC-CCA. Overall survival and disease-free survival were significantly worse in cases with CD133-positive (P = 0.048 and P = 0.048, respectively) or EpCAM-positive (P = 0.041 and P = 0.041, respectively) CCA component in cHCC-CCA. Conclusions INT and CCA components showed higher expression rates of cancer stem cell markers than the HCC component. CD133 or EpCAM expression in the CCA component was associated with poor prognosis in cHCC-CCA.
Rights: This is the peer reviewed version of the following article: Kazuki Wakizaka, Hideki Yokoo, Toshiya Kamiyama, Tatsuhiko Kakisaka, Masafumi Ohira, Michio Tani, Koichi Kato, Yuki Fujii, Ko Sugiyama, Akihisa Nagatsu, Shingo Shimada, Tatsuya Orimo, Hirofumi Kamachi, Ryosuke Matsuoka, Akinobu Taketomi. (2020) Hepatology Research: 50(2):258-267., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 脇坂 和貴

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