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Rapidly progressive organizing pneumonia associated with COVID-19

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Title: Rapidly progressive organizing pneumonia associated with COVID-19
Authors: Horii, Hiroshi Browse this author
Kamada, Keisuke Browse this author
Nakakubo, Sho Browse this author
Yamashita, Yu Browse this author
Nakamura, Junichi Browse this author
Nasuhara, Yasuyuki Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Keywords: SARS-CoV-2
Organizing pneumonia
Krebs von den lungen 6 (KL-6)
Surfactant protein (SP-D)
Issue Date: 2020
Publisher: Elsevier
Journal Title: Respiratory Medicine Case Reports
Volume: 31
Start Page: 101295
Publisher DOI: 10.1016/j.rmcr.2020.101295
Abstract: We report a case of clinically diagnosed secondary organizing pneumonia (SOP) associated with coronavirus disease 2019 (COVID-19). A 70-year-old woman who had been diagnosed with COVID-19 was admitted to Hokkaido University Hospital. Although her fever, cough, dyspnea, and serum C-reactive protein levels improved, she developed rapidly progressive respiratory failure and computed tomography revealed the development of bilateral lung consolidation. Her dyspnea was relieved, and her oxygenation levels and radiological findings improved after commencing corticosteroid treatment. Blood biomarkers for interstitial lung disease, Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D), showed different responses during the clinical course of her disease. Evaluation of serial changes in levels of KL-6 and SP-D may help diagnose and monitor COVID-19-associated organizing pneumonia (OP). Clinicians should be aware that SOP can develop in response to COVID-19 and that these patients may benefit from the use of steroids.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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