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Tetracycline plus macrolide : A potential therapeutic regimen for COVID-19?

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Title: Tetracycline plus macrolide : A potential therapeutic regimen for COVID-19?
Authors: Ohe, Masashi Browse this author
Furuya, Ken Browse this author
Goudarzi, Houman Browse this author →KAKEN DB
Keywords: tetracycline
macrolide
COVID-19
SARS-CoV-2
Issue Date: 2020
Journal Title: BioScience Trends
Volume: 14
Issue: 6
Start Page: 467
End Page: 468
Publisher DOI: 10.5582/bst.2020.03443
Abstract: The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that struck in late 2019 and early 2020 is a serious threat to human health. Since there are no approved drugs that satisfactorily treat this condition, all efforts at drug design and/or clinical trials are warranted and reasonable. Drug repurposing is a well-known strategy that seeks to deploy existing licensed drugs for newer indications and that provides the quickest possible transition from the bench to the bedside to meet therapeutic needs. At present, several existing licensed drugs such as chloroquine, hydroxychloroquine, methylprednisolone, dexamethasone, and remdesivir have been used because of their potential efficacy in inhibiting COVID-19. Recently, antibiotics such as tetracyclines and macrolides have been reported to be effective against COVID-19. A combination of tetracyclines and macrolides may be a potential treatment for COVID-19 because there are some differences in the mechanism of action of tetracyclines and macrolides.
Type: article
URI: http://hdl.handle.net/2115/80474
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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