| Title: | Calcium Wave Promotes Cell Extrusion |
| Authors: | Takeuchi, Yasuto Browse this author →KAKEN DB |
| Narumi, Rika Browse this author |
| Akiyama, Ryutaro Browse this author →KAKEN DB |
| Vitiello, Elisa Browse this author |
| Shirai, Takanobu Browse this author |
| Tanimura, Nobuyuki Browse this author →KAKEN DB |
| Kuromiya, Keisuke Browse this author |
| Ishikawa, Susumu Browse this author |
| Kajita, Mihoko Browse this author →KAKEN DB |
| Tada, Masazumi Browse this author |
| Haraoka, Yukinari Browse this author |
| Akieda, Yuki Browse this author →KAKEN DB |
| Ishitani, Tohru Browse this author →KAKEN DB |
| Fujioka, Yoichiro Browse this author →KAKEN DB |
| Ohba, Yusuke Browse this author →KAKEN DB |
| Yamada, Sohei Browse this author →KAKEN DB |
| Hosokawa, Yoichiroh Browse this author →KAKEN DB |
| Toyama, Yusuke Browse this author |
| Matsui, Takaaki Browse this author →KAKEN DB |
| Fujita, Yasuyuki Browse this author →KAKEN DB |
| Issue Date: | 24-Feb-2020 |
| Publisher: | Cell Press |
| Journal Title: | Current biology |
| Volume: | 30 |
| Issue: | 4 |
| Start Page: | 670 |
| End Page: | 681 |
| Publisher DOI: | 10.1016/j.cub.2019.11.089 |
| Abstract: | When oncogenic transformation or apoptosis occurs within epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial homeostasis. However, the underlying molecular mechanism still remains elusive. In this study, we first show, using mammalian cultured epithelial cells and zebrafish embryos, that prior to apical extrusion of RasV12-transformed cells, calcium wave occurs from the transformed cell and propagates across the surrounding cells. The calcium wave then triggers and facilitates the process of extrusion. IP3 receptor, gap junction, and mechanosensitive calcium channel TRPC1 are involved in calcium wave. Calcium wave induces the polarized movement of the surrounding cells toward the extruding transformed cells. Furthermore, calcium wave facilitates apical extrusion, at least partly, by inducing actin rearrangement in the surrounding cells. Moreover, comparable calcium propagation also promotes apical extrusion of apoptotic cells. Thus, calcium wave is an evolutionarily conserved, general regulatory mechanism of cell extrusion. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/80478 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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