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Calcium Wave Promotes Cell Extrusion

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Title: Calcium Wave Promotes Cell Extrusion
Authors: Takeuchi, Yasuto Browse this author →KAKEN DB
Narumi, Rika Browse this author
Akiyama, Ryutaro Browse this author →KAKEN DB
Vitiello, Elisa Browse this author
Shirai, Takanobu Browse this author
Tanimura, Nobuyuki Browse this author →KAKEN DB
Kuromiya, Keisuke Browse this author
Ishikawa, Susumu Browse this author
Kajita, Mihoko Browse this author →KAKEN DB
Tada, Masazumi Browse this author
Haraoka, Yukinari Browse this author
Akieda, Yuki Browse this author →KAKEN DB
Ishitani, Tohru Browse this author →KAKEN DB
Fujioka, Yoichiro Browse this author →KAKEN DB
Ohba, Yusuke Browse this author →KAKEN DB
Yamada, Sohei Browse this author →KAKEN DB
Hosokawa, Yoichiroh Browse this author →KAKEN DB
Toyama, Yusuke Browse this author
Matsui, Takaaki Browse this author →KAKEN DB
Fujita, Yasuyuki Browse this author →KAKEN DB
Issue Date: 24-Feb-2020
Publisher: Cell Press
Journal Title: Current biology
Volume: 30
Issue: 4
Start Page: 670
End Page: 681
Publisher DOI: 10.1016/j.cub.2019.11.089
Abstract: When oncogenic transformation or apoptosis occurs within epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial homeostasis. However, the underlying molecular mechanism still remains elusive. In this study, we first show, using mammalian cultured epithelial cells and zebrafish embryos, that prior to apical extrusion of RasV12-transformed cells, calcium wave occurs from the transformed cell and propagates across the surrounding cells. The calcium wave then triggers and facilitates the process of extrusion. IP3 receptor, gap junction, and mechanosensitive calcium channel TRPC1 are involved in calcium wave. Calcium wave induces the polarized movement of the surrounding cells toward the extruding transformed cells. Furthermore, calcium wave facilitates apical extrusion, at least partly, by inducing actin rearrangement in the surrounding cells. Moreover, comparable calcium propagation also promotes apical extrusion of apoptotic cells. Thus, calcium wave is an evolutionarily conserved, general regulatory mechanism of cell extrusion.
Rights: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤田 恭之

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