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Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression

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Title: Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression
Authors: Endo, Hiraku Browse this author
Hama, Naoki Browse this author
Baghdadi, Muhammad Browse this author →KAKEN DB
Ishikawa, Kozo Browse this author →KAKEN DB
Otsuka, Ryo Browse this author
Wada, Haruka Browse this author →KAKEN DB
Asano, Hiroshi Browse this author
Endo, Daisuke Browse this author
Konno, Yosuke Browse this author →KAKEN DB
Kato, Tatsuya Browse this author
Watari, Hidemichi Browse this author →KAKEN DB
Tozawa, Akiko Browse this author →KAKEN DB
Suzuki, Nao Browse this author →KAKEN DB
Yokose, Tomoyuki Browse this author →KAKEN DB
Takano, Atsushi Browse this author →KAKEN DB
Kato, Hisamori Browse this author
Miyagi, Yohei Browse this author →KAKEN DB
Daigo, Yataro Browse this author →KAKEN DB
Seino, Ken-Ichiro Browse this author →KAKEN DB
Keywords: disease stage
ovarian cancer
overall survival
progression-free survival
Issue Date: Mar-2020
Publisher: Oxford University Press
Journal Title: International immunology
Volume: 32
Issue: 3
Start Page: 175
End Page: 186
Publisher DOI: 10.1093/intimm/dxz074
Abstract: Ovarian cancer is the second-most lethal gynecological malignancy and the seventh-commonest cause of cancer-related death in women around the world. Most of the ovarian cancer patients are diagnosed at advanced stages and suffer from recurrence after primary cytoreductive surgery and standard first-line chemotherapy. Thus, the successful management of ovarian cancer patients requires the identification of factors that contribute to progression and relapse. Interleukin-34 (IL-34) is a novel cytokine that acts as a tissue-specific ligand of colony-stimulating factor-1 receptor (CSF-1R). In cancer, IL-34 exerts pro-tumorigenic functions that promote tumor growth, metastasis, angiogenesis, immune suppression and therapeutic resistance. In this study, we evaluate the impact of IL-34 on progression and survival of ovarian cancer patients. First, IL-34 was found to be expressed in several human ovarian cancer cell lines and cancer tissues from patients. The expression of IL-34 was enhanced by cytotoxic chemotherapy in ovarian cancer cell lines and cancer tissues from chemotherapy-treated ovarian cancer patients. Importantly, high IL-34 expression correlated with worse progression-free survival (PFS) and overall survival in different cohorts. The assessment of PFS based on a combination between IL34 expression and other related genes such as CSF1R and CD163 helped further to reach more statistical significance compared with IL34 alone. Furthermore, in the murine ovarian cancer cell HM-1 in vivo model, it was suggested that IL-34-derived tumor cells was correlated with tumor progression and survival by modulating the immune environment. Collectively, these findings indicate a possible correlation between IL-34 expression and disease progression in ovarian cancer patients and the mouse model.
Rights: This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record Hiraku Endo, Naoki Hama, Muhammad Baghdadi, Kozo Ishikawa, Ryo Otsuka, Haruka Wada, Hiroshi Asano, Daisuke Endo, Yosuke Konno, Tatsuya Kato, Hidemichi Watari, Akiko Tozawa, Nao Suzuki, Tomoyuki Yokose, Atsushi Takano, Hisamori Kato, Yohei Miyagi, Yataro Daigo, Ken-ichiro Seino, Interleukin-34 expression in ovarian cancer: a possible correlation with disease progression, International Immunology, Volume 32, Issue 3, March 2020, Pages 175-186., is available online at:
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清野 研一郎

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