|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Institute for Genetic Medicine >
Peer-reviewed Journal Articles, etc >
Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression
| Title: | Interleukin-34 expression in ovarian cancer : a possible correlation with disease progression |
| Authors: | Endo, Hiraku Browse this author | | Hama, Naoki Browse this author | | Baghdadi, Muhammad Browse this author →KAKEN DB | | Ishikawa, Kozo Browse this author →KAKEN DB | | Otsuka, Ryo Browse this author | | Wada, Haruka Browse this author →KAKEN DB | | Asano, Hiroshi Browse this author | | Endo, Daisuke Browse this author | | Konno, Yosuke Browse this author →KAKEN DB | | Kato, Tatsuya Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB | | Tozawa, Akiko Browse this author →KAKEN DB | | Suzuki, Nao Browse this author →KAKEN DB | | Yokose, Tomoyuki Browse this author →KAKEN DB | | Takano, Atsushi Browse this author →KAKEN DB | | Kato, Hisamori Browse this author | | Miyagi, Yohei Browse this author →KAKEN DB | | Daigo, Yataro Browse this author →KAKEN DB | | Seino, Ken-Ichiro Browse this author →KAKEN DB |
| Keywords: | disease stage | | interleukin-34 | | ovarian cancer | | overall survival | | progression-free survival |
| Issue Date: | Mar-2020 |
| Publisher: | Oxford University Press |
| Journal Title: | International immunology |
| Volume: | 32 |
| Issue: | 3 |
| Start Page: | 175 |
| End Page: | 186 |
| Publisher DOI: | 10.1093/intimm/dxz074 |
| Abstract: | Ovarian cancer is the second-most lethal gynecological malignancy and the seventh-commonest cause of cancer-related death in women around the world. Most of the ovarian cancer patients are diagnosed at advanced stages and suffer from recurrence after primary cytoreductive surgery and standard first-line chemotherapy. Thus, the successful management of ovarian cancer patients requires the identification of factors that contribute to progression and relapse. Interleukin-34 (IL-34) is a novel cytokine that acts as a tissue-specific ligand of colony-stimulating factor-1 receptor (CSF-1R). In cancer, IL-34 exerts pro-tumorigenic functions that promote tumor growth, metastasis, angiogenesis, immune suppression and therapeutic resistance. In this study, we evaluate the impact of IL-34 on progression and survival of ovarian cancer patients. First, IL-34 was found to be expressed in several human ovarian cancer cell lines and cancer tissues from patients. The expression of IL-34 was enhanced by cytotoxic chemotherapy in ovarian cancer cell lines and cancer tissues from chemotherapy-treated ovarian cancer patients. Importantly, high IL-34 expression correlated with worse progression-free survival (PFS) and overall survival in different cohorts. The assessment of PFS based on a combination between IL34 expression and other related genes such as CSF1R and CD163 helped further to reach more statistical significance compared with IL34 alone. Furthermore, in the murine ovarian cancer cell HM-1 in vivo model, it was suggested that IL-34-derived tumor cells was correlated with tumor progression and survival by modulating the immune environment. Collectively, these findings indicate a possible correlation between IL-34 expression and disease progression in ovarian cancer patients and the mouse model. |
| Rights: | This is a pre-copyedited, author-produced version of an article accepted for publication in International immunology following peer review. The version of record Hiraku Endo, Naoki Hama, Muhammad Baghdadi, Kozo Ishikawa, Ryo Otsuka, Haruka Wada, Hiroshi Asano, Daisuke Endo, Yosuke Konno, Tatsuya Kato, Hidemichi Watari, Akiko Tozawa, Nao Suzuki, Tomoyuki Yokose, Atsushi Takano, Hisamori Kato, Yohei Miyagi, Yataro Daigo, Ken-ichiro Seino, Interleukin-34 expression in ovarian cancer: a possible correlation with disease progression, International Immunology, Volume 32, Issue 3, March 2020, Pages 175-186., is available online at: https://doi.org/10.1093/intimm/dxz074 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/80503 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 清野 研一郎
|
