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Silent pituitary adenoma and metabolic disorders : obesity, abnormal glucose tolerance, hypertension and dyslipidemia

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Title: Silent pituitary adenoma and metabolic disorders : obesity, abnormal glucose tolerance, hypertension and dyslipidemia
Authors: Baba, Natsuki Browse this author
Kameda, Hiraku Browse this author →KAKEN DB
Nakamura, Akinobu Browse this author →KAKEN DB
Yong Cho, Kyu Browse this author
Nomoto, Hiroshi Browse this author →KAKEN DB
Mitsuhashi, Tomoko Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Silent pituitary adenoma
Growth hormone
Metabolic disorder
Issue Date: 2021
Publisher: The Japan Endocrine Society
Journal Title: Endocrine Journal
Volume: 68
Issue: 2
Start Page: 195
End Page: 200
Publisher DOI: 10.1507/endocrj.EJ20-0185
Abstract: A silent pituitary adenoma (SPA) is characterized by the expression of pituitary hormones, detected by immunohistochemical staining, in the absence of clinical signs or symptoms of hormonal excess. Compared with functional pituitary adenomas, little is known regarding the involvement of SPAs in metabolic disorders. This study aimed to examine the correlations between SPAs and metabolic disorders, including obesity, abnormal glucose tolerance, hypertension and dyslipidemia. Seventy-four patients with nonfunctional pituitary adenomas who underwent a pituitary adenomectomy in Hokkaido University Hospital from 2008 to 2016 were retrospectively examined. Pituitary adenomas were immunohistochemically classified into pituitary hormone positive or negative groups. Twenty whole hormone-negative pituitary adenomas were excluded because we couldn’t identify pituitary transcription factors which is necessary for the diagnosis of a null cell adenoma. The preoperative rates of obesity, abnormal glucose tolerance, hypertension and dyslipidemia were compared between each group. Twenty-seven GH positive adenomas (50.0%), 32 gonadotroph positive adenomas (59.3%), 28 TSH positive adenomas (51.9%) and 21 ACTH positive adenomas (38.9%) were identified. Evaluation of the preoperative clinical data showed 25 cases of obesity (46.2%), 16 cases of abnormal glucose tolerance (29.6%), 29 cases of hypertension (53.7%) and 35 cases of dyslipidemia (64.8%). The rate of hypertension was significantly lower in the GH positive group (37.0%) than the GH negative group (70.4%) (p = 0.0140). In the GH negative group, postoperative systolic and diastolic blood pressure levels were significantly lower than preoperative values. GH positive SPAs may affect the homeostasis of blood pressure.
Type: article
URI: http://hdl.handle.net/2115/80509
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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