HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Institute of Low Temperature Science >
Peer-reviewed Journal Articles, etc >

High mobility of lattice molecules and defects during the early stage of protein crystallization

Files in This Item:
softmatter_16(8)_1955_1960.pdf389.06 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: High mobility of lattice molecules and defects during the early stage of protein crystallization
Authors: Yamazaki, Tomoya Browse this author
Van Driessche, Alexander E. S. Browse this author
Kimura, Yuki Browse this author →KAKEN DB
Issue Date: 28-Feb-2020
Publisher: Royal Society of Chemistry
Journal Title: Soft matter
Volume: 16
Issue: 8
Start Page: 1955
End Page: 1960
Publisher DOI: 10.1039/c9sm02382h
Abstract: Protein crystals are expected to be useful not only for their molecular structure analysis but also as functional materials due to their unique properties. Although the generation and the propagation of defects during crystallization play critical roles in the final properties of protein crystals, the dynamics of these processes are poorly understood. By time-resolved liquid-cell transmission electron microscopy, we observed that nanosized crystal defects are surprisingly mobile during the early stages of the crystallization of a lysozyme as a model protein. This highly dynamic behavior of defects reveals that the lattice molecules are mobile throughout the crystal structure. Moreover, the disappearance of the defects indicated that intermolecular bonds can break and reform rapidly with little energetic cost, as reported in theoretical studies. All these findings are in marked contrast to the generally accepted notion that crystal lattices are rigid with very limited mobility of individual lattice molecules.
Type: article (author version)
Appears in Collections:低温科学研究所 (Institute of Low Temperature Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 勇気

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University