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Hokkaido University Collection of Scholarly and Academic Papers >
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Critical Roles of PIWIL1 in Human Tumors : Expression, Functions, Mechanisms, and Potential Clinical Implications
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Critical Roles of PIWIL1 in Human Tumors : Expression, Functions, Mechanisms, and Potential Clinical Implications |
| Authors: | Dong, Peixin Browse this author →KAKEN DB | | Xiong, Ying Browse this author | | Konno, Yosuke Browse this author →KAKEN DB | | Ihira, Kei Browse this author →KAKEN DB | | Xu, Daozhi Browse this author | | Kobayashi, Noriko Browse this author | | Yue, Junming Browse this author | | Watari, Hidemichi Browse this author →KAKEN DB |
| Keywords: | piRNA | | PIWIL1 | | HIWI | | tumorigenesis | | cancer metastasis | | prognostic biomarker | | EMT | | chemoresistance |
| Issue Date: | 2021 |
| Journal Title: | Frontiers in Cell and Developmental Biology |
| Volume: | 9 |
| Start Page: | 656993 |
| Publisher DOI: | 10.3389/fcell.2021.656993 |
| Abstract: | P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24?31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming piRNA/PIWI complexes that influence gene expression at the transcriptional or post-transcriptional levels. However, it has been recently reported that the interaction of PIWI proteins with piRNAs does not encompass the entire function of PIWI proteins in human tumor cells. PIWIL1 (also called HIWI) is specifically expressed in the testis but not in other normal tissues. In tumor tissues, PIWIL1 is frequently overexpressed in tumor tissues compared with normal tissues. Its high expression is closely correlated with adverse clinicopathological features and shorter patient survival. Upregulation of PIWIL1 drastically induces tumor cell proliferation, epithelial-mesenchymal transition (EMT), invasion, cancer stem-like properties, tumorigenesis, metastasis and chemoresistance, probably via piRNA-independent mechanisms. In this article, we summarize the current existing literature on PIWIL1 in human tumors, including its expression, biological functions and regulatory mechanisms, providing new insights into how the dysregulation of PIWIL1 contributes to tumor initiation, development and chemoresistance through diverse signaling pathways. We also discuss the most recent findings on the potential clinical applications of PIWIL1 in cancer diagnosis and treatment. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/80514 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 董 培新
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